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A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set6.H3K27Ac and H3K4me2 ChIP-Seq cerebellum P18 WT]

ABSTRACT: A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set6.H3K27Ac and H3K4me2 ChIP-Seq cerebellum P18 WT]

PROVIDER: PRJNA1028973 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26410127.fastq.gz	Fastqsanger.gz
	SRR26410128.fastq.gz	Fastqsanger.gz
	SRR26410129.fastq.gz	Fastqsanger.gz
	SRR26410130.fastq.gz	Fastqsanger.gz
	SRR26410131.fastq.gz	Fastqsanger.gz

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A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set6.H3K27Ac and H3K4me2 ChIP-Seq cerebellum P18 WT]

Project description:During retinogenesis, the proneural bHLH transcription factor Atoh7 is transiently expressed in retinal progenitor cells (RPCs) and is required for retinal ganglion cell (RGC) differentiation. In humans, a deletion in a distal non-coding regulatory region upstream of ATOH7 is associated with nonsyndromic congenital retinal nonattachment (NCRNA) disorder, characterized by optic nerve atrophy and complete blindness. Here we functionally interrogate the significance of the Atoh7 enhancer landscape to retinogenesis. We demonstrate that deletion of the enhancer structure upstream of Atoh7 in mice leads to RGC deficiency, optic nerve hypoplasia and blood vascular abnormalities, phenocopying inactivation of Atoh7 and recapitulating key features of NCRNA. We further provide evidence that the loss of the Atoh7 remote enhancer impacts ipsilaterally-projecting RGCs and disrupts proper axonal projections to the brain targets. Transcriptionally, deletion of the Atoh7 remote enhancer is associated with dysregulation of axonogenesis genes, including the derepression of the axon repulsive cue Robo3 which is normally epigenetically silenced in the developing retina. Our data provide novel insights into how Atoh7 enhancer elements function to promote RGC development and optic nerve formation and uncover a key role of Atoh7 in the transcriptional control of axon guidance molecules possibly via epigenetic mechanisms.

2024-06-06 | GSE245544 | GEO

A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set7.Bulk RNA-Seq P18 Cerebellum WT and Atoh7 Large Enhancer KO]

Project description:A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set7.Bulk RNA-Seq P18 Cerebellum WT and Atoh7 Large Enhancer KO]

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A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set8.Bulk RNA-Seq P18 Cerebellum WT and Atoh7 remote Enhancer KO]

Project description:A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set8.Bulk RNA-Seq P18 Cerebellum WT and Atoh7 remote Enhancer KO]

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A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis

Project description:A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis

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A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set8.Bulk RNA-Seq P18 Cerebellum WT and Atoh7 remote Enhancer KO]

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Project description:A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set1.Sc-ATAC-Seq retina E14.5 WT retina]

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A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis [Set1.Sc-ATAC-Seq retina E14.5 WT retina]

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A cis-regulatory module underlies retinal ganglion cell genesis and axonogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

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P18 knockout

Project description:Mice used were in a mixed background between 129/SvEv and C57BL/6. They were Rp1 knockout mice (Rp1-/-). Triplicates of RNA samples from Rp1-/- neural retinas for hybridization were collected at P18. Each RNA sample included a pool of neural retinas from 3-4 mice. Retinas were all collected at 1-2 pm of the day. Keywords: repeat sample

2004-04-15 | GSE126 | GEO

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