Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of the downstream target genes of TGFbeta

ABSTRACT: Identification of the downstream target genes of TGFbeta

PROVIDER: PRJNA1028988 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26410321_1.fastq.gz	Fastqsanger.gz
	SRR26410321_2.fastq.gz	Fastqsanger.gz
	SRR26410322_1.fastq.gz	Fastqsanger.gz
	SRR26410322_2.fastq.gz	Fastqsanger.gz
	SRR26410323_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Identification of the downstream target genes of TGFbeta

Project description:This study aimed to explore the downstream target genes of TGFbeta in normal gastric cell line GES-1.

2024-01-31 | GSE245557 | GEO

Identification of downstream target genes of NR2F1 in gastric cancer

Project description:Identification of downstream target genes of NR2F1 in gastric cancer

| PRJNA975159 | ENA

Identification of the downstream target genes of miR-138 in gastric cancer

Project description:Identification of the downstream target genes of miR-138 in gastric cancer

| PRJNA761583 | ENA

Identification of LIN-29 target genes

Project description:Identification of LIN-29 target genes

| PRJNA485538 | ENA

Identification of NOTCH3 unique target genes

Project description:Identification of NOTCH3 unique target genes

| PRJNA524386 | ENA

Identification of downstream target genes of NR2F1 in gastric cancer

Project description:This study aims to identify the downstream target genes of NR2F1 in gastric cancer.

2023-09-30 | GSE233167 | GEO

Identification of DDX5 target genes in spermatogonia

Project description:Identification of DDX5 target genes in spermatogonia

| PRJNA433512 | ENA

Genome-wide identification of PPD2 target genes

Project description:Genome-wide identification of PPD2 target genes

| PRJEB7643 | ENA

Identification of CaMKII-dependent H3S28p target genes

Project description:Identification of CaMKII-dependent H3S28p target genes

| PRJEB32860 | ENA

Application of blood transcriptomics to identify three novel biomarkers for monitoring anti-TGFbeta therapy

Project description:Background: Development of target specific therapeutics greatly benefits from simultaneous identification of biomarkers to determine aspects of bioactivity, drug safety and efficacy or even treatment outcome. This is particularly important when targeting pleiotropic factors such as the TGFbeta system. TGFbeta has become a prime target for cancer therapeutics since inhibition of TGFbeta signaling simultaneously attacks the tumor and its microenvironment. Methods: Here we introduce blood transcriptomics followed by a defined set of validation assays as a promising approach to identify novel biomarkers for monitoring TGFbeta therapy. Findings: Our initial genome-wide analysis of transcription in peripheral blood revealed 12 candidate genes specifically regulated in peripheral blood by the TGFbeta receptor I kinase inhibitor LY2109761. In subsequent in vitro and in vivo molecular and immunological analyses, the combined monitoring of gene regulation of three genes, namely TMEPAI, OCIAD2, and SMAD7 was established as novel biomarkers for anti-TGFbeta based therapies. Interpretation: Overall, the proposed algorithm of biomarker identification is easily adapted towards other drug candidates for which gene regulation can be established in peripheral blood.

2010-07-20 | GSE15468 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data