Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Carbapenemase Producing Organisms

ABSTRACT: Clinical Carbapenemase Producing Organism Genomic Surveillance

PROVIDER: PRJNA1030769 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26458392_1.fastq.gz	Fastqsanger.gz
	SRR26458393_1.fastq.gz	Fastqsanger.gz
	SRR26458393_2.fastq.gz	Fastqsanger.gz
	SRR26458394_1.fastq.gz	Fastqsanger.gz
	SRR26458395_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

National Surveillance of Carbapenemase-Producing Organisms

Project description:National Surveillance of Carbapenemase-Producing Organisms

| PRJEB75178 | ENA

Carbapenemase Producing E.coli Ireland

Project description:Carbapenemase Producing E.coli Ireland

| PRJEB19435 | ENA

Whole transcriptomic analysis of mechanisms of tolerance and resistance to chlorhexidine in carbapenemase-producing Klebsiella pneumoniae clinical strains

Project description:The increasing resistence and/or bacterial tolerance to bactericides, such as chlorhexidine, causes worrisome public health problems. Using transcriptomical and microbiological studies, we analysed the molecular mechanisms associated with the adaptation to chlorhexidine in two carbapenemase-producing strains of Klebsiella pneumoniae belonging ST258-KPC3 and ST846-OXA48.

2020-03-21 | GSE147316 | GEO

Carbapenemase-producing Enterobacteriaceae

Project description:Carbapenemase-producing Enterobacteriaceae isolated from Hong Kong, China

| PRJNA595034 | ENA

Carbapenemase producing E.cloacae complex Ireland

Project description:Carbapenemase producing E.cloacae complex Ireland

| PRJEB22264 | ENA

Genomic diversity of carbapenemase-producing Providencia stuartii clinical isolates from Bulgaria

Project description:Genomic diversity of carbapenemase-producing Providencia stuartii clinical isolates from Bulgaria

| PRJEB70804 | ENA

Clinical Evaluation of Advanced MALDI-TOF MS for Carbapenemase Subtyping in Gram-negative Isolates

Project description:The spread of carbapenemase-producing Enterobacterales (CPE) is emerging as a significant clinical concern in tertiary hospitals and in particular, long-term care facilities with deficiencies in infection control. This study aims to evaluate an advanced matrix-assisted laser desorption/ionization mass spectrometry (A-MALDI) method for the identification of carbapenemases and further discrimination of their subtypes in clinical isolates. The A-MALDI method was employed to detect CPE target proteins. Enhancements were made to improve detectability and mass accuracy through the optimization of MALDI-TOF settings and internal mass calibration. A total of 581 clinical isolates were analyzed, including 469 CPE isolates (388 KPC, 51 NDM, 40 OXA, and 2 GES) and 112 carbapenemase-negative isolates. Clinical evaluation of the A-MALDI demonstrated 100% accuracy and precision in identifying all the collected CPE isolates. Additionally, A-MALDI successfully discriminated individual carbapenemase subtypes (KPC-2 or KPC-3/4; OXA-48 or OXA-181 or OXA-232; GES-5 or GES-24) and also differentiated co-producing carbapenemase strains (KPC & NDM; KPC & OXA; KPC & GES; NDM & OXA), attributed to its high mass accuracy and simultaneous detection capability. A-MALDI is considered a valuable diagnostic tool for accurately identifying CPE and carbapenemase’s subtypes in clinical isolates. It may also aid in selecting appropriate antibiotics for each carbapenemase subtype. Ultimately, we expect that the A-MALDI method will contribute to preventing the spread of antibiotic resistance and improving human public health.

2024-11-26 | PXD058284 | Pride

Clinical Evaluation of Advanced MALDI-TOF MS for Carbapenemase Subtyping in Gram-negative Isolates

2024-11-25 | PXD046179 | Pride

First dataset - bacterial proteome of carbapanemase-producing Escherichia coli and other Enterobacteriaceae under antibiotic pressure

Project description:Antibiotic resistance associated with the expression of the clinically significant carbapenemases, IMP, KPC, and NDM and OXA-48 in Enterobacteriaceae is emerging as a worldwide calamity to health care. In Australia, IMP-producing Enterobacteriaceae is the most prevalent carbapenemase-producing Enterobacteriaceae (CPE). Genomic characteristics of such carbapenemase-producing Enterobacteriaceae (CPE) are well described, but the corresponding proteome is poorly characterised. We have thus developed a method to analyse dynamic changes in the proteome of CPE under antibiotic pressure. Specifically, we have investigated the effect of meropenem at sub-lethal concentrations to develop a better understanding of how antibiotic pressure leads to resistance. Escherichia coli, producing either NDM, IMP or KPC type carbapenemase were included in this study, and their proteomes were analysed in growth conditions with or without meropenem.

2018-07-11 | PXD008019 | Pride

Surveillance of carbapenemase-producing Klebsiella pneumoniae in Russia, Belarus and Kazakhstan

Project description:Surveillance of carbapenemase-producing Klebsiella pneumoniae in Russia, Belarus and Kazakhstan

| PRJEB49683 | ENA