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Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [miRNA]

ABSTRACT: Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [miRNA]

PROVIDER: PRJNA1031613 | ENA |

REPOSITORIES: ENA

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Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [circRNA]

Project description:Cadmium is a naturally existing heavy metal and a typical environmental pollutant which is a significant threat to human health and can lead to acute and chronic damage to various organs. At present, hundreds of lncRNAs and miRNAs have been confirmed to be related to the toxicity of Cd. However, the role of circRNA in the toxicity of Cd and the involved regulatory mechanism has not been clarified. In this work, human normal liver cell (L-02) was selected as model to identify the changes in the expression level of circRNA after exposure to Cd. Total RNA of each sample was extracted by Trizol method, the original data of circRNA, miRNA and mRNA expression levels of each sample were obtained by microarray hybridization and scanning were standardized and differentially expressed. Differential circRNAs, miRNAs, and mRNAs associated with the toxic effects of Cd were identified. Construct a ceRNA network by screening the predicted circRNA, miRNA and mRNA and predict the main biological functions and metabolic pathways of the network. A total of 266 different circRNAs, 223 different miRNAs and 519 different mRNAs were identified by differential expression analysis. After screening, seven circRNAs, 10 miRNAs and 97 mRNAs were constructed into ceRNA network. After GO enrichment and KEGG pathway analysis of 97 mRNAs in circRNA-miRNA-mRNA network, indicated that circRNA in the ceRNA network may regulate cell proliferation, apoptosis, oxidative stress and inflammatory response under the toxic effect of Cd to damage L-02, and it has obvious dose-response effect and time effect.

2024-10-08 | GSE246129 | GEO

Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [miRNA]

2024-10-08 | GSE246130 | GEO

Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [mRNA]

2024-10-08 | GSE246131 | GEO

Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [circRNA]

Project description:Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [circRNA]

| PRJNA1031612 | ENA

Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model

Project description:Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model

| PRJNA1031609 | ENA

Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [mRNA]

Project description:Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model [mRNA]

| PRJNA1031614 | ENA

Environmental cadmium-induced circRNA-miRNA-mRNA network regulatory mechanism in human normal liver cell model

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-08 | GSE246132 | GEO

cadmium-mirna-cadmium stress on suspension cells.

Project description:rs06-03_cd-mirna - cadmium-mirna - trancriptional and post-transcriptional response to cadmium. - After 5 days of grown in a fresh medium (5% PCV at day0), CdCl2 was added to tested cells (Cad) to a final concentration of 200uM. Nothing was added to control cells (Tem). After 12 and 24 hours of growth +/- cadmium, cells were harvested and frozen in liquid nitrogen.

2012-03-25 | GSE36627 | GEO

cadmium-mirna-cadmium stress on suspension cells.

2012-03-25 | E-GEOD-36627 | biostudies-arrayexpress

Daphnia miRNA expression data from Cadmium exposed and none-exposed samples

Project description:We used Affymetrix microarrays to profile the Dapnia pulex miRNA expression under Cadmium exposure and identified Cadmium-responsive miRNAs

2015-10-15 | GSE68481 | GEO

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