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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells.

ABSTRACT: Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells.

PROVIDER: PRJNA1032473 | ENA |

REPOSITORIES: ENA

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Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [RNA-seq]

Project description:In this study, the retinoid and vitamin D pathways were investigated in PMA-differentiated THP-1 cells treated with or without the RARa agonist, AM580, and/or the VDR agonist, 1,25-dihydroxyvitamin D3 (1,25-vitD or calcitriol), using global approaches. Binding regions of RARa and VDR were determined in PMA-differentiated THP-1 cells using chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq). The gene sets regulated by AM580 and/or 1,25-vitD were identified by RNA-sequencing (RNA-seq). The activity of the regulatory regions was determined and chromatin openness was measured using assay for transposase-accessible chromatin with sequencing (ATAC-seq).

2024-12-31 | GSE246309 | GEO

Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ChIP-seq]

Project description:In this study, the retinoid and vitamin D pathways were investigated in PMA-differentiated THP-1 cells treated with or without the RARa agonist, AM580, and/or the VDR agonist, 1,25-dihydroxyvitamin D3 (1,25-vitD or calcitriol), using global approaches. Binding regions of RARa and VDR were determined in PMA-differentiated THP-1 cells using chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq). The gene sets regulated by AM580 and/or 1,25-vitD were identified by RNA-sequencing (RNA-seq). The activity of the regulatory regions was determined by MED1 (a subunit of the Mediator complex) ChIP-seq and chromatin openness was measured using assay for transposase-accessible chromatin with sequencing (ATAC-seq).

2024-12-31 | GSE246308 | GEO

Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [RNA-seq]

Project description:Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [RNA-seq]

| PRJNA1032481 | ENA

Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ATAC-seq]

Project description:Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ATAC-seq]

| PRJNA1032482 | ENA

Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ChIP-seq]

Project description:Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ChIP-seq]

| PRJNA1032483 | ENA

Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells.

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-12-31 | GSE246310 | GEO

Retonic acid and vitamin D signalling pathways converge at genomic regions co-occupied by RARa and VDR in differentiated THP-1 cells [ATAC-seq]

Project description:The activity of the regulatory regions was determined by MED1 (a subunit of the Mediator complex) ChIP-seq and chromatin openness was measured using assay for transposase-accessible chromatin with sequencing (ATAC-seq).

2024-12-31 | GSE246307 | GEO

Genome-wide map of vitamin D receptor (VDR) binding in THP-1 cells

Project description:Analysis of acute effects of ligand-treatment on vitamin D receptor binding genome-wide using ChIP-seq. THP-1 monocytic leucemia cells were treated with 1?,25(OH)2D3 (1,25D) or left unstimulated to investigate the acute effects of VDR chromatin occupancy. We identified in total 2340 VDR binding sites with and without the ligand. Without the ligand, there is a considerable presence of VDR already on the chromatin. However, upon a short (40 min) ligand treatment VDR shifts from sites that rarely contain a DR3 type element to sites that frequently contain one or more DR3-type element. Genome-wide identification of VDR binding in THP-1 cells at the unstimulated state and after 40 min ligand (10 nM 1?,25(OH)2D3 (1,25D, calcitriol)) treatment.

2011-08-17 | E-GEOD-27437 | biostudies-arrayexpress

Genome-wide map of vitamin D receptor (VDR) binding in THP-1 cells

2011-08-17 | GSE27437 | GEO

Effects of vitamin D on VDR binding in THP-1 cells

Project description:Three independent repeats of ChIP-seq or ChIPmentation with THP-1 cells after treatment with either 1,25(OH)2D3 (VD) or control (EtOH) using antibody against VDR.

2024-09-30 | GSE124056 | GEO

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