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Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [colonocytes]

ABSTRACT: Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [colonocytes]

PROVIDER: PRJNA1033339 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26557416.fastq.gz	Fastqsanger.gz
	SRR26557417.fastq.gz	Fastqsanger.gz
	SRR26557418.fastq.gz	Fastqsanger.gz
	SRR26557419.fastq.gz	Fastqsanger.gz
	SRR26557420.fastq.gz	Fastqsanger.gz

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Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes

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Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [HCT116]

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Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [colonocytes]

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Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [HCT116]

Project description:Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [HCT116]

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Project description:The epithelial-mesenchymal transition (EMT) is a key developmental program that is often activated during cancer progression and may promote resistance to therapy. An analysis of patients (n = 71) profiled with both gene expression and a global microRNA assessment (~ 415 miRs) identified miR-147 as highly anti-correlated with an EMT gene expression signature score and postulated to reverse EMT (MET).We have found that miR-147 induced cancer cells to undergo MET phenotypically. It's necessary to investigate the genes affected by miR-147 to understand the mechanism. RNA extracted from miR-147 and non-coding miR transiently transfected HCT116 cells; gene expression then assayed using the Affymetrix GeneChip U133 Plus2.0 platform.

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Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes

Project description:This SuperSeries is composed of the SubSeries listed below.

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miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy (mRNA)

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