Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [ChIP-seq]

ABSTRACT: Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [ChIP-seq]

PROVIDER: PRJNA1033600 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26590104_1.fastq.gz	Fastqsanger.gz
	SRR26590104_2.fastq.gz	Fastqsanger.gz
	SRR26590105_1.fastq.gz	Fastqsanger.gz
	SRR26590105_2.fastq.gz	Fastqsanger.gz
	SRR26590106.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 120

Similar Datasets

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [RNA-seq]

Project description:Brain development requires appropriate regulation of serotonin (5-HT) signaling from distinct tissue sources across embryogenesis. At the maternal-fetal interface, the placenta is thought to be an important contributor of offspring brain 5-HT and is critical to overall fetal health. Yet, how placental 5-HT is acquired, and the mechanisms through which 5-HT influences placental functions, are not well understood. Recently, our group identified a novel epigenetic role for 5-HT, in which 5-HT can be added to histone proteins to regulate transcription, a process called H3 serotonylation. Here, we show that H3 serotonylation undergoes dynamic regulation during placental development, corresponding to gene expression changes that are known to influence key metabolic processes. Using transgenic mice, we demonstrate that placental H3 serotonylation largely depends on 5-HT uptake by the serotonin transporter (Sert/Slc6a4). Sert deletion robustly reduces enrichment of H3 serotonylation across the placental genome, and disrupts neurodevelopmental gene networks in offspring brain tissues. Thus, these findings suggest a novel role for H3 serotonylation in coordinating placental transcription at the intersection of maternal physiology and offspring brain development.

2024-01-23 | GSE246539 | GEO

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [ChIP-seq]

2024-01-23 | GSE246538 | GEO

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome

Project description:Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome

| PRJNA1033596 | ENA

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [RNA-seq]

Project description:Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [RNA-seq]

| PRJNA1033602 | ENA

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome.

Project description:Brain development requires appropriate regulation of serotonin (5-HT) signaling from distinct tissue sources across embryogenesis. At the maternal-fetal interface, the placenta is thought to be an important contributor of offspring brain 5-HT and is critical to overall fetal health. Yet, how placental 5-HT is acquired, and the mechanisms through which 5-HT influences placental functions, are not well understood. Recently, our group identified a novel epigenetic role for 5-HT, in which 5-HT can be added to histone proteins to regulate transcription, a process called H3 serotonylation. Here, we show that H3 serotonylation undergoes dynamic regulation during placental development, corresponding to gene expression changes that are known to influence key metabolic processes. Using transgenic mice, we demonstrate that placental H3 serotonylation largely depends on 5-HT uptake by the serotonin transporter (SERT/SLC6A4). SERT deletion robustly reduces enrichment of H3 serotonylation across the placental genome, and disrupts neurodevelopmental gene networks in early embryonic brain tissues. Thus, these findings suggest a novel role for H3 serotonylation in coordinating placental transcription at the intersection of maternal physiology and offspring brain development.

| S-EPMC10680709 | biostudies-literature

Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-23 | GSE246540 | GEO

Histone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways

Project description:Histone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways

| PRJNA1031155 | ENA

Histone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways [ChIP-Seq]

Project description:Histone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways [ChIP-Seq]

| PRJNA1031369 | ENA

Histone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways [RNA-seq]

Project description:Histone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways [RNA-seq]

| PRJNA1031368 | ENA

Gene Expression and Histopathological Changes in the Placenta of the Serotonin Transporter (Slc6a4) Knockout Mouse Suggest a Role for Serotonin in Controlling Nutrient Acquisition

Project description:Gene Expression and Histopathological Changes in the Placenta of the Serotonin Transporter (Slc6a4) Knockout Mouse Suggest a Role for Serotonin in Controlling Nutrient Acquisition

| PRJNA732506 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data