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Trappc1 is essential for naive T cell survival

ABSTRACT: Trappc1 is essential for naive T cell survival

PROVIDER: PRJNA1034162 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26623191_1.fastq.gz	Fastqsanger.gz
	SRR26623191_2.fastq.gz	Fastqsanger.gz
	SRR26623192_1.fastq.gz	Fastqsanger.gz
	SRR26623192_2.fastq.gz	Fastqsanger.gz
	SRR26623193_1.fastq.gz	Fastqsanger.gz

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Trappc1 is essential for naive T cell survival

Project description:T lymphocytes are pivotal in adaptive immunity. The role of trafficking protein particle complex (TRAPPC) in regulating T cell development and homeostasis are unknown. Using CD4cre-Trappc1flox/flox (Trappc1 cKO) mice, we found that Trappc1 deficiency in T cells significantly decreased cell number of naïve T cells in the periphery, whereas thymic T cell development in Trappc1 cKO mice was identical as in WT mice. In the culture assays and mouse models with adoptive transfer of the sorted WT (CD45.1+CD45.2+) and Trappc1 cKO naive T cells (CD45.2+) to CD45.1+ syngeneic mice, Trappc1-deficienct naive T cells showed significantly reduced survival ability compared with WT cells. RNA-seq and molecular studies showed that Trappc1 deficiency in naive T cells reduced protein transport from the endoplasmic reticulum to Golgi apparatus, enhanced unfolded protein responses, increased P53 transcription, intracellular Ca2+, Atf4-CHOP, oxidative phosphorylation and lipid peroxide accumulation, and subsequently led to ferroptosis.

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