Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CUT&Tag seq analysis of histone variant H2BE in neurons [H2BE_CT_antibodyValidation]

ABSTRACT: CUT&Tag seq analysis of histone variant H2BE in neurons [H2BE_CT_antibodyValidation]

PROVIDER: PRJNA1034551 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26627506_1.fastq.gz	Fastqsanger.gz
	SRR26627506_2.fastq.gz	Fastqsanger.gz
	SRR26627507_1.fastq.gz	Fastqsanger.gz
	SRR26627507_2.fastq.gz	Fastqsanger.gz
	SRR28819369_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

CUT&Tag seq analysis of histone variant H2BE in neurons

Project description:CUT&Tag seq analysis of histone variant H2BE in neurons

| PRJNA1033991 | ENA

CUT&Tag seq analysis of histone variant H2BE in neurons

Project description:Histone variant H2BE Analysis of histone variant H2BE in neuronal chromatin

2024-07-17 | GSE246618 | GEO

CUT&Tag seq analysis of histone variant H2BE in neurons [H2BE_CT_antibodyValidation]

Project description:Analysis of histone variant H2BE in neuronal chromatin

2024-07-17 | GSE246748 | GEO

CUT&Tag, ATAC-seq, bulk RNA-seq and single-nucleus RNA-seq analysis of histone variant H2BE in cortical neurons

Project description:CUT&Tag, ATAC-seq, bulk RNA-seq and single-nucleus RNA-seq analysis of histone variant H2BE in cortical neurons

| PRJNA1034122 | ENA

Genome-wide location analysis of FLAG-H2BE

Project description:We have identified a replication-independent histone variant, Hist2h2be (referred to herein as H2be), which is expressed exclusively by olfactory chemosensory neurons. Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to the identity of the co-expressed olfactory receptor (OR). Gain- and loss-of-function experiments demonstrate that changes in H2be expression affect olfactory function and OR representation in the adult olfactory epithelium. We show that H2BE expression is reduced by sensory activity and that it promotes neuronal cell death, such that inactive olfactory neurons display higher levels of the variant and shorter life spans. Post-translational modifications (PTMs) of H2BE differ from those of the canonical H2B, consistent with a role for H2BE in altering transcription. We propose a physiological function for H2be in modulating olfactory neuron population dynamics to adapt the OR repertoire to the environment. The objective of generating this dataset was to analyze the occupancy of H2BE protein in the vicinity of gene promoters throughout the genome, relative to histone H3, in olfactory sensory neurons within the main olfactory epithelium (MOE). This dataset analyzes the occupancy of FLAG-H2BE protein in the vicinity of gene promoters throughout the genome, relative to histone H3, in olfactory sensory neurons within the main olfactory epithelium (MOE) of Flag-H2be transgenic mice, which express a FLAG-tagged version of H2BE from the H2be promoter. There are 2 replicates for each ChIP (FLAG and H3).

2012-09-01 | E-GEOD-39517 | biostudies-arrayexpress

Genome-wide location analysis of FLAG-H2BE

2012-09-01 | GSE39517 | GEO

ChIP-seq analysis of histone variant H2BE in neuronal chromatin

Project description:ChIP-seq analysis of histone variant H2BE in neuronal chromatin

2024-07-17 | GSE265987 | GEO

ATAC-seq analysis of histone variant H2BE in neuronal chromatin

Project description:ATAC-seq analysis of histone variant H2BE in neuronal chromatin

2024-07-17 | GSE246739 | GEO

ATAC-seq analysis of mutant histone variant H2BE in neuronal chromatin

Project description:ATAC-seq analysis of mutant histone variant H2BE in neuronal chromatin

2024-07-17 | GSE265986 | GEO

CUT&Tag assay for ATF4 in C57BL/6 primarily cultured neurons.

Project description:To elucidate the biological role of ATF4 in regulating downstream target genes, we conducted a CUT&Tag assay in primarily cultured neurons.

2024-09-13 | GSE263464 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data