Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic changes in HCT116 cells after KAT2A knockout

ABSTRACT: Transcriptomic changes in HCT116 cells after KAT2A knockout

PROVIDER: PRJNA1035047 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26642048_1.fastq.gz	Fastqsanger.gz
	SRR26642048_2.fastq.gz	Fastqsanger.gz
	SRR26642049_1.fastq.gz	Fastqsanger.gz
	SRR26642049_2.fastq.gz	Fastqsanger.gz
	SRR26642050_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Transcriptomic changes in HCT116 cells after KAT2A knockout

Project description:We were interested in transcriptional changes after depletion of histone acetyltransferase KAT2A in human colorectal cancer. Therefore, we utilized HCT116 cells as model, and analyzed global alterations of gene expression.

2024-11-01 | GSE246881 | GEO

Transcriptomic changes in primary intestinal epithelium cells with Kat2a/Kat2b DKO.

Project description:Transcriptomic changes in primary intestinal epithelium cells with Kat2a/Kat2b DKO.

| PRJNA987626 | ENA

Gene expression changes in human colorectal cell line HCT116 DICER Exon5 knockout cells

Project description:The experiment was to study the gene expression changes in human colorectal cell HCT116 DICER Exon5 knockout cells comparing to that in parental HCT116 cellls. Keywords: Cell type comparison

2007-10-26 | GSE6427 | GEO

Transcriptomic changes in primary intestinal epithelium cells with Kat2a/Kat2b DKO.

Project description:RNA-seq was conducted to determine differentially expressed genes in whole intestinal epithelial cells between Kat2a/Kat2b DKO and controls.

2023-08-31 | GSE235789 | GEO

Kat2a regulates hippocampal memory formation [RNA-seq]

Project description:We sequenced mRNA from 24 samples extracted from mouse CA1 tissue to generate the first CA1-specific murine transcriptome and the first CA1-transcriptome in response to environmental novelty under normal and Kat2a-loss-of-function conditions. Samples were divded in 4 groups: A: Control naM-CM-/ve (n=6), B: control novelty-exposed (n=5), C: Kat2a cKO naM-CM-/ve (n=6), D: Kat2a cKO novelty-exposed (n=7). Pairwise comparisons for AvsB, AvsC, BvsD and CvsD were performed using DESeq2.

2014-07-16 | E-GEOD-53380 | biostudies-arrayexpress

Transcription profiling of human colorectal cell line HCT116 DICER Exon5 knockout cells

2008-06-14 | E-GEOD-6427 | biostudies-arrayexpress

Distinct contributions of KAT2A histone acetyl-transferase complexes to human erythropoiesis

Project description:KAT2A is a histone acetyl-transferase involved in stabilization of transcriptional activity through acetylation of lysine residue 9 of Histone 3. Mouse knockout models suggest that Kat2a is dispensable for haematopoietic stem and progenitor cell activity, despite a central role in survival and maintenance of Acute Myekoid Leukaemia cells through block of differentiation. Herein, we investigate KAT2A activity in human cord blood haematopoiesis and identify a specific requirement in the establishment of the erythroid lineage. KAT2A is required for specification and survival of Erythroid-Megakaryocytic progenitors, with regulation of expression of the erythropoietin receptor (EPOR) gene, which participates in lineage commitment, as well as of later effector genes in the platelet and erythroid lineages. Early and late lineage roles can be distinctly attributed to the ATAC and SAGA complexes in which context KAT2A exerts its activity. ATAC is active earlier in erythroid lineage development and mediates MEP specification from HSC, whilst SAGA activity is required post-commitment, including in expression of haemoglobin genes. We thus position KAT2A as a novel regulator of human erythropoiesis and separate early and later effects in lineage development with complex specificity. This has implications for putative therapeutic targeting of KAT2A complexes in leukaemia.

2021-09-28 | GSE128512 | GEO

Kat2a regulates hippocampal memory formation [small RNA-seq]

Project description:We sequenced small RNAs from 12 samples extracted from mouse CA1 tissue to generate the first CA1-specific murine miRNome under normal and Kat2a-loss-of-function conditions. Samples were divded in 4 groups: A: Control (n=6), C: Kat2a cKO naÃ¯ve (n=6)

2014-07-16 | E-GEOD-53427 | biostudies-arrayexpress

Distinct contributions of KAT2A histone acetyl-transferase complexes to human erythropoiesis [RNA-seq]

2021-09-28 | GSE128902 | GEO

ZKSCAN3 knockout HCT116 colorectal cancer cell line

Project description:ZKSCAN3 knockout HCT116 colorectal cancer cell line

| PRJNA722415 | ENA