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Combined anti-inflammatory and regenerative therapies rescue skeletal muscle after IRI through multi-pathway activation

ABSTRACT: Combined anti-inflammatory and regenerative therapies rescue skeletal muscle after IRI through multi-pathway activation

PROVIDER: PRJNA1035445 | ENA |

REPOSITORIES: ENA

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Combined anti-inflammatory and regenerative therapies rescue skeletal muscle after IRI through multi-pathway activation

Project description:Ten-week-old C57BL/6J mice were subjected to unilateral hind limb ischemia-reperfusion (I/R) injury by postural suspension method for 4 hours, and then treated with aspirin anti-inflammatory group and peptide functionalized hydrogel drug. RNA-seq analysis was then performed.

2023-11-15 | GSE246962 | GEO

Gene expression change in Keap1 knockdown (KD) mice in kidneys of ischemia-reperfusion injury (IRI)

Project description:We analyzed differences in IRI kidneys between WT and Keap1 KD mice (= Nrf2-activated mice). To identify Nrf2-target genes or metabolic genes in kidneys, we examined the mRNA expression profile both in normal (uninjured) and IRI kidneys (at day1 after unilateral IRI) from mice We performed microarray analyses using 1) Injured kidneys at day 1 after unilateral IRI, and 2) intact kidneys from mice which did not undergo UIRI. Samples were harvested from Keap1 KD mice and WT mice, n = 2 each,

2016-04-01 | E-GEOD-71647 | biostudies-arrayexpress

Ischemia reperfusion injury (IRI) in organ transplantation and the effects of carbon monoxide treatment

Project description:Ischemia reperfusion injury (IRI) in organ transplantation remains a significant problem with limited alternative therapeutic options. Organs that undergo significant damage during IRI, particularly those enduring long warm ischemia times, undergo significant delayed graft function (DGF) after reperfusion and tend to have greater complications long term with the onset of chronic rejection. The gas molecule carbon monoxide (CO) has emerged as an agent that can suppress IRI in rodent models of solid organ transplantation. Since the use of CO is a potential therapeutic modality in humans, we tested if CO can prevent DGF in a pig model of kidney transplantation Keywords: stress response, treatment response 18 Samples from pig kidneys, two naïve controls, two timepoints, two conditions, 4 replicates

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Ornithobacterium rhinotracheale strain:IRI-Sh

Project description:Ornithobacterium rhinotracheale strain:IRI-Sh Genome sequencing

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Gene expression change in Keap1 knockdown (KD) mice in kidneys of ischemia-reperfusion injury (IRI)

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Single-cell RNA-seq in mouse kidneys after IRI

Project description:We performed Drop-seq using dissociated total kidney cells to identify cell types, gene expression patterns and signaling pathways in mouse kidneys after IRI.

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Ischemia reperfusion injury (IRI) in organ transplantation and the effects of carbon monoxide treatment

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Effect of knockout of ALKBH5 on gene expression and m6A modifications during IRI in mice

Project description:To identify the direct m6A demethylation targets of ALKBH5 at the onset of renal IRI, we performed methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing (RNA-seq) using RNA isolated from IRI mouse kidney of WT and KO mice 24h after I/R (WT n=3 vs. KO n=3)

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Genes encoding cognate receptors for IRI-related recipient cytokines are expressed in donor livers

Project description:Purpose: RNAseq was used to look in donor allografts for genes encoding cytokine receptors specific to the cytokines identified to be upregulated in the blood of Orthotopic liver transplantation (OLT) receipients with ischemia reperfusion injury (IRI) Methods: Liver mRNA cytokine receptor profiles of allografts taken before and after transplant, demultiplexed with Illumina CASAVA, trimmed with Cutadapt, aligned to hg38 with STAR, counted with featureCounts Results: We identified expression of genes encoding 10 cognate receptors for the 14 potential cytokines found to be upregulated in IRI+ patients. Conclusion: Many of the cytokines that are upregulated in the blood of IRI+ OLT recipients have cognate receptors present in donor livers that could allow completed signaling pathways to occur

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SMARCA4 Rescue Profiling

Project description:SMARCA4 Rescue Profiling

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