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BCG vaccination stimulates Integrated Organ Immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance [GeoMx]

ABSTRACT: BCG vaccination stimulates Integrated Organ Immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance [GeoMx]

PROVIDER: PRJNA1036287 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26685800_1.fastq.gz	Fastqsanger.gz
	SRR26685800_2.fastq.gz	Fastqsanger.gz
	SRR26685900_1.fastq.gz	Fastqsanger.gz
	SRR26685900_2.fastq.gz	Fastqsanger.gz
	SRR26685801_1.fastq.gz	Fastqsanger.gz

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BCG vaccination stimulates Integrated Organ Immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance [GeoMx]

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BCG vaccination stimulates Integrated Organ Immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

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Project description:The century-old Mycobacterium bovis Bacillus Calmette-Guerin (BCG) remains the only licensed vaccine against tuberculosis (TB). Despite this, there is still a lot to learn about the immune response induced by BCG, both in terms of phenotype and specificity. Here, we investigated the BCG-specific gene expression changes induced in PBMCs and CD4 memory T cells by BCG in individuals pre- and 8m post vaccination. We also determined whether reactivity against a peptide pool defined in individuals with controlled latent TB infection (MTB300), and with peptides homologous to peptides found in BCG, was boosted following BCG vaccination.

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