Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Streptomyces griseus subsp. griseus NBRC 13350

ABSTRACT: Effect of AdpA deficient

PROVIDER: PRJNA103875 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Streptomyces griseus subsp. griseus NBRC 13350

Project description:Effect of AdpA deficiency on S. griseus cells grown in SMM medium

| PRJNA112153 | ENA

Streptomyces griseus transcriptome analysis in liquid culture with delta adpA, encoding a global transcriptional regulator involved in morphological differentiation and secondary metabolism

Project description:To identify genes regulated by AdpA in liquid culture, transcriptome profiles between delta adpA strains with his-adpA and control delta adpA strains were analyzed.

2012-04-04 | GSE33993 | GEO

Streptomyces griseus transcriptome analysis in solid culture with delta adpA, encoding a global transcriptional regulator involved in morphological differentiation and secondary metabolism

Project description:To identify genes regulated by AdpA in solid culture, transcriptome profiles between delta adpA strains with his-adpA and control delta adpA strains were analyzed.

2012-04-04 | GSE33992 | GEO

Streptomyces griseus subsp. griseus NBRC 13350

Project description:Time course effect of A-factor addition

| PRJNA110569 | ENA

Effect of AdpA deficiency on S. griseus cells grown in SMM medium

Project description:Comparative hybridization of wild type versus AdpA deficient mutant grown on SMM medium

2009-03-07 | GSE14770 | GEO

Streptomyces clavuligerus Transcriptome using adpA deleted and overexpressed mutants

Project description:RNA seq analysis was performed using adpA-deleted and adpA-overexpressed Streptomyces clavuligerus strains to determine its regulatory effect on tunicamycin and other secondary metabolites production

2024-07-01 | GSE243267 | GEO

Effect of AdpA deficiency on S. griseus cells grown in SMM medium

Project description:Comparative hybridization of wild type versus AdpA deficient mutant grown on SMM medium 3 x dual channel slides, dye swap

2010-05-22 | E-GEOD-14770 | biostudies-arrayexpress

Draft Genome Sequence of Streptomyces hygroscopicus subsp. hygroscopicus NBRC 16556.

Project description:Here, we report the draft genome sequence of strain NBRC 16556, deposited as Streptomyces hygroscopicus subsp. hygroscopicus into the NBRC culture collection. An average nucleotide identity analysis confirmed that the taxonomic identification is correct. The genome sequence will serve as a valuable reference for genome mining to search new secondary metabolites.

| S-EPMC4889001 | biostudies-literature

Streptomyces griseus

Project description:A new AdpA-dependent gene, required for morphological differentiation, in Streptomyces griseus.

| PRJNA157279 | ENA

Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.

Project description:Chromomycin A3 is an antitumor drug produced by Streptomyces griseus subsp. griseus. It consists of a tricyclic aglycone with two aliphatic side chains and two O-glycosidically linked saccharide chains, a disaccharide of 4-O-acetyl-D-oliose (sugar A) and 4-O-methyl-D-oliose (sugar B), and a trisaccharide of D-olivose (sugar C), D-olivose (sugar D), and 4-O-acetyl-L-chromose B (sugar E). The chromomycin gene cluster contains four glycosyltransferase genes (cmmGI, cmmGII, cmmGIII, and cmmGIV), which were independently inactivated through gene replacement, generating mutants C60GI, C10GII, C10GIII, and C10GIV. Mutants C10GIV and C10GIII produced the known compounds premithramycinone and premithramycin A1, respectively, indicating the involvement of CmmGIV and CmmGIII in the sequential transfer of sugars C and D and possibly also of sugar E of the trisaccharide chain, to the 12a position of the tetracyclic intermediate premithramycinone. Mutant C10GII produced two new tetracyclic compounds lacking the disaccharide chain at the 8 position, named prechromomycin A3 and prechromomycin A2. All three compounds accumulated by mutant C60GI were tricyclic and lacked sugar B of the disaccharide chain, and they were named prechromomycin A4, 4A-O-deacetyl-3A-O-acetyl-prechromomycin A4, and 3A-O-acetyl-prechromomycin A4. CmmGII and CmmGI are therefore responsible for the formation of the disaccharide chain by incorporating, in a sequential manner, two D-oliosyl residues to the 8 position of the biosynthetic intermediate prechromomycin A3. A biosynthetic pathway is proposed for the glycosylation events in chromomycin A3 biosynthesis.

| S-EPMC1352227 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data