Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling [V]

ABSTRACT: Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling [V]

PROVIDER: PRJNA1039827 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling.

Project description:Coordinated metabolic reprogramming and epigenetic remodeling are critical for modulating T cell function and differentiation. However, how the epigenetic modification controls Th17/Treg cell balance via metabolic reprogramming remains obscure. Here, we find that Setd2, a histone H3K36 trimethyltransferase, suppresses Th17 development but promotes iTreg cell polarization via phospholipid remodeling. Mechanistically, Setd2 up-regulates transcriptional expression of lysophosphatidylcholine acyltransferase 4 (Lpcat4) via directly catalyzing H3K36me3 of Lpcat4 gene promoter in T cells. Lpcat4-mediated phosphatidylcholine PC(16:0,18:2) generation in turn limits endoplasmic reticulum stress and oxidative stress. These changes decrease HIF-1α transcriptional activity and thus suppress Th17 but enhance Treg development. Consistent with this regulatory paradigm, T cell deficiency of Setd2 aggravates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis due to imbalanced Th17/Treg cell differentiation. Overall, our data reveal that Setd2 acts as an epigenetic brake for T cell-mediated autoimmunity through phospholipid remodeling, suggesting potential targets for treating neuroinflammatory diseases.

| S-EPMC10895270 | biostudies-literature

Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling [V]

Project description:Purpose: RNA-seq analysis of gene expression patterns in Naïve t, Th0, Treg and Th17 cells of wild-type mice. The goals of this study are to compared the gene expression between Naïve T and other types Th cells by RNA-seq analysise.

2024-12-31 | GSE247616 | GEO

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling

| PRJNA987673 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [II]

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [II]

| PRJNA987681 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [IV]

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [IV]

| PRJNA987678 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [I]

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [I]

| PRJNA987680 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [III]

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [III]

| PRJNA987679 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [II]

Project description:Purpose: RNA-seq analysis of gene expression in Treg cells from wild-type and Setd2-CD4 cre mice. The goals of this study are to compared the gene expression between wildtype and Setd2-CD4 cre mice Treg cells by RNA-seq analysise.

2024-12-31 | GSE235825 | GEO

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [IV]

Project description:Purpose: RNA-seq analysis of gene expression in Th0 cells from wild-type and Setd2-CD4 cre mice. The goals of this study are to compared the gene expression between wildtype and Setd2-CD4 cre mice Th0 cells by RNA-seq analysise.

2024-12-31 | GSE235822 | GEO

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling [I]

Project description:Purpose: RNA-seq analysis of gene expression in Th17 cells from wild-type and Setd2-CD4 cre mice. The goals of this study are to compared the gene expression between wildtype and Setd2-CD4 cre mice Th17 cells by RNA-seq analysise.

2024-12-31 | GSE235826 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data