Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Skin regional specification and higher-order HoxC regulation [Micro-C]

ABSTRACT: Skin regional specification and higher-order HoxC regulation [Micro-C]

PROVIDER: PRJNA1040308 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Skin regional specification and higher-order HoxC regulation [Micro-C]

Project description:The integument plays a critical role in functional adaptation, with macro-regional specification forming structures like beaks, combs, feathers, and scales, while micro-regional specification modifies skin appendage shapes. However, the molecular mechanisms remain largely unknown. Craniofacial integument displays dramatic diversity, exemplified by the Polish chicken (PC) with a homeotic transformation of comb-to-crest feathers, caused by a 195–base pair (bp) duplication in HoxC10 intron. Micro-C analyses show that HoxC-containing topologically associating domain (TAD) is normally closed in the scalp but open in the dorsal and tail regions, allowing multiple long-distance contacts. In the PC scalp, the TAD is open, resulting in high HoxC expression. CRISPR-Cas9 deletion of the 195-bp duplication reduces crest feather formation, and HoxC misexpression alters feather shapes. The 195-bp sequence is found only in Archelosauria (crocodilians and birds) and not in mammals. These findings suggest that higher-order regulation of the HoxC cluster modulates gene expression, driving the evolution of adaptive integumentary appendages in birds.

2025-03-25 | GSE247780 | GEO

Skin regional specification and higher-order HoxC regulation [ATAC-Seq]

2025-03-25 | GSE247779 | GEO

Skin regional specification and higher-order HoxC regulation [RNA-Seq]

2025-03-25 | GSE247778 | GEO

Skin regional specification and higher-order HoxC regulation

Project description:Skin regional specification and higher-order HoxC regulation

| PRJNA1040303 | ENA

Skin regional specification and higher-order HoxC regulation [ATAC-Seq]

Project description:Skin regional specification and higher-order HoxC regulation [ATAC-Seq]

| PRJNA1040307 | ENA

Skin regional specification and higher-order HoxC regulation [RNA-Seq]

Project description:Skin regional specification and higher-order HoxC regulation [RNA-Seq]

| PRJNA1040301 | ENA

Skin regional specification and higher-order HoxC regulation

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-03-25 | GSE247782 | GEO

DNA methylation maintains integrity of higher order genome architecture

Project description:DNA methylation maintains integrity of higher order genome architecture

| PRJNA663616 | ENA

Higher-Order Organization Principles of Pre-translational mRNPs [RIPPLiT]

Project description:Higher-Order Organization Principles of Pre-translational mRNPs [RIPPLiT]

| PRJNA476057 | ENA

Higher-order spatial organization of the Deinococcus radiodurans chromosomes

Project description:Higher-order spatial organization of the Deinococcus radiodurans chromosomes

| PRJNA1008341 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data