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Doris montereyensis

ABSTRACT: Doris montereyensis overview

PROVIDER: PRJNA1040398 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR23080714_1.fastq.gz	Fastqsanger.gz
	SRR23080714_2.fastq.gz	Fastqsanger.gz
	SRR23080715_1.fastq.gz	Fastqsanger.gz
	SRR23080715_2.fastq.gz	Fastqsanger.gz

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Project description:Remission is the established therapeutic goal for patients with systemic lupus erythematosus (SLE) and is currently defined by the widely adopted Definition Of Remission In SLE (DORIS) criteria. Attainment of remission is rare in the clinical setting, thus an alternative, pragmatic treatment target of low disease activity, as defined by the Lupus Low Disease Activity State (LLDAS), provides a less stringent and more attainable treatment goal for a wider proportion of patients compared with DORIS remission. Randomized controlled trials and real-world analyses have confirmed the positive clinical benefits of achieving either DORIS remission or LLDAS. The treat-to-target (T2T) approach utilizes practical clinical targets to proactively tailor individual treatment regimens. Studies in other chronic inflammatory diseases using the T2T approach demonstrated significantly improved clinical outcomes and quality-of-life measures compared with established standard of care. However, such trials have not yet been performed in patients with SLE. Here we review the evolution of DORIS remission and LLDAS definitions and the evidence supporting the positive clinical outcomes following DORIS remission or LLDAS attainment, before discussing considerations for implementation of these outcome measures as potential T2T objectives. Adoption of DORIS remission and LLDAS treatment goals may result in favorable patient outcomes compared with established standard of care for patients with SLE.

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RNA-Seq data for: Evolution of sex-biased gene expression and dosage compensation in the eye and brain of Heliconius butterflies

Project description:RNA was extracted using Trizol from heads of 5 Heliconius species: H. erato, H. charithonia, H. melpomene, H. doris and H. sara. An illumina TruSeq kit was used to generate RNA-Seq libraries which were sequenced using 100 bp paired-end sequencing. Sequence data was used to compare gene expression between males and females within species. Differentially expressed genes were annotated for functions and compared across species. Data was also used to detect for dosage compensation in all species.

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Multiple <i>Doris</i> "<i>kerguelenensis</i>" (Nudibranchia) species span the Antarctic Polar Front.

Project description:Despite strong historical biogeographical links between benthic faunal assemblages of the Magellan region of South America and the Antarctic Peninsula, very few studies have documented contemporary movement and gene flow in or out of the Southern Ocean, especially across the Antarctic Polar Front (APF). In fact, oceanographic barriers such as the APF and Antarctica's long geologic isolation have substantially separated the continents and facilitated the evolution of endemic marine taxa found within the Antarctic region. The Southern Ocean benthic sea slug complex, Doris "kerguelenensis," are a group of direct-developing, simultaneous hermaphrodites that lack a dispersive larval stage. To date, there are 59 highly divergent species known within this complex. Here, we provide evidence to show intraspecific genetic connectivity occurs across the APF for multiple species within the D. "kerguelenensis" nudibranch species complex. We addressed questions of genetic connectivity by examining the phylogeographic structure of the three best-sampled D. "kerguelenensis" species and another three trans-APF species using the protein coding mtDNA gene, cytochrome oxidase I. We also highlight alternative refugia uses among species with the same life history traits (i.e., benthic and direct developers) and for some species, extremely large distributions are established (e.g., circumpolarity). By improving our sampling of these nudibranchs, we gain better insight into the population structure and connectivity of the Antarctic region. This work also demonstrates how difficult it is to make generalizations across Antarctic marine species, even among ecologically-similar, closely related species.

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