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Homo sapiens

ABSTRACT: Comparison of gene expression data between wild-type and DM1-affected undifferentiated hES cells.

OTHER RELATED OMICS DATASETS IN: E-GEOD-7179

PROVIDER: PRJNA104049 | ENA |

REPOSITORIES: ENA

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Comparison of gene expression data between wild-type and DM1-affected cells

Project description:This SuperSeries is composed of the following subset Series: GSE7177: Comparison of gene expression data between wild-type and DM1-affected Mesodermal Precursors Cells (MPC) GSE7178: Comparison of gene expression data between wild-type and DM1-affected Neural Precursors Cells (NPC) GSE7179: Comparison of gene expression data between wild-type and DM1-affected undifferentiated hES cells. Keywords: SuperSeries Refer to individual Series

2010-03-09 | E-GEOD-7214 | biostudies-arrayexpress

E-GEOD-7179

Project description:Comparison of gene expression data between wild-type and DM1-affected undifferentiated hES cells.

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Project description:Comparison of gene expression data between wild-type and DM1-affected cells

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Transcriptome analysis between wild-type and DM1-affected fibroblast.

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Overview of gene expression alternatively modulated during the differentiation of human embryonic stem cells (hES)

Project description:The transcriptome analysis was performed in triplicate using two human embryonic stem cells lines (hES_VUB01 and hES_SA01) by comparing the expression profiles of the undifferentiated hES cells and two types of progenitors derived from the hES cell lines: Neural progenitors (NPC) and Mesodermal progenitors (MSC). Keywords: Cell type comparison

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Integrative proteogenomics for differential expression and splicing variation in a DM1 mouse model

Project description:Here, we performed a large-scale coordinated transcriptomic and proteomic analysis to characterize a DM1 mouse model (HSALR) in comparison to wild-type. Our integrative proteogenomics approach comprised gene- and splicing-level assessments for mRNA and protein. It recapitulated many known instances of aberrant mRNA splicing in DM1 and identified new ones. It enabled the design and targeting of splicing-specific peptides and confirmed the translation of known instances of aberrantly spliced disease-related genes (e.g. Atp2a1, Bin1, Ryr1), complemented by novel findings (e.g. Ywhae, Flnc, Svil). Comparative analysis of large-scale mRNA and protein expression data showed remarkable agreement of differential patterns between disease and wild-type on both the gene and especially the splicing level.

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microRNA expression profiling among human embryonic stem cells, differerentiated EBs and adult cells

Project description:Human embryonic stem (hES) cells have unique features: self-renewal ability and pluripotency. They can be continuously cultured in undifferentiated state and give rise to cells and tissues of all three germ layers. Thus hES cells provide a resource not only for cell replacement therapy but also for studying human developmental biology. We aimed to identify the unique signature of miRNAs in human embryonic stem cells. Keywords: cell type comparison design

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