Project description:MDSC (myeloid-derived suppressor cells) can be divided into two subsets: granulocytic MDSC (G-MDSC) and monocyte MDSC (M-MDSC).We found that CHBP induced M-MDSC have stronger immunosuppressive function. To identify the specific role of CHBP induced M-MDSC, we used RNA squencing to compare the M-MDSC with CHBP induced M-MDSC. We analyzed the differential expressed genes between these two groups.
Project description:We characterized difference immune cell subsets in liver microenvironment between PBC mouse models (mainly dnTGFβRII mice) and wild type mouse by transcriptome and proteome single cell squencing, and discovered an unconventional cytotoxic CD8αα T cells increased in dnTGFβRII mice.
Project description:Purpose: Our lab has previously shown that Scleraxis (Scx) is require for proper valve development in vivo. In order to fully explore gene networks regulated by Scx during the vital stages of valve remodeling , high throughput RNA-squencing was performed. Results:There were a total of 18,810 genes were detected. A total of 864 genes were differentially expressed Scx null AVC regions: 645 being upregulated and 217 downregulated.