Capra hircus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA104163 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Impact of CSN1S1 polymorphism on mammary transcriptome of food-deprived lactating goats
| PRJNA104165 | ENA
Project description:Impact of food-deprivation on mammary transcriptome of lactating goats
| PRJNA99551 | ENA
Project description:Goat's alphaS1-casein (CSN1S1) polymorphism has a significant effect on milk protein and lipid composition, which affects the nutritional quality and technological properties of milk. Moreover, this polymorphism has a large impact on the morphology of mammary epithelial cells. To explore the metabolic pathways modulated in relation to this polymorphism, we compared the mammary gene expression profiles of two groups of lactating goats carrying either two reference or two defective alleles, using a bovine oligonucleotide microarray representing 8379 genes. We identified 41 differentially expressed genes between the two genotype groups. In particular, we showed a downregulation of two key lipogenic genes encoding fatty acid synthase and glycerol-3-phosphate acyltransferase in agreement with the low fat concentration associated with CSN1S1 deficiency. In addition, this study highlights changes in the expression level of several genes known to influence membrane fluidity, cell-cell interaction or chromatin organization. Our results open up new fields of investigation on structural modifications associated with CSN1S1 deficiency that could affect mammary gland function. Keywords: SuperSeries This SuperSeries is composed of the following subset Series: GSE6637: Impact of CSN1S1 polymorphism on mammary transcriptome of lactating goats GSE6642: Impact of CSN1S1 polymorphism on mammary transcriptome of food-deprived lactating goats. Refer to individual Series
2010-05-27 | E-GEOD-6646 | biostudies-arrayexpress
Project description:Shotgun Metagenome of Lactating goats (Capra hircus)
| PRJNA1026506 | ENA
Project description:Extruded linseed alone or in combination with fish oil modifies mammary gene expression profiles in lactating goats
| PRJNA282082 | ENA
Project description:Liver profiles of mid-lactating goats using Agilent Array
| PRJNA219173 | ENA
Project description:Genetic (animal species, breed and genotype) has a considerable effect on milk composition. In particular, goats present a remarkable polymorphism at the alpha-S1-casein (CSN1S1) locus which results in large differences in milk protein content and indirectly in milk fat content and its fatty acids composition. In order to decipher the mammary metabolic pathways involved, we examined the effect of CSN1S1 polymorphism on the expression of 8,379 genes in caprine mammary gland using a bovine oligonucleotide microarray. Six 48-h food-deprived lactating goats were assigned to 2 groups based on their genotype at the CSN1S1 locus: High vs. Low genotype goats carrying, respectively, two reference alleles associated with high CSN1S1 synthesis and two defective alleles associated with low CSN1S1 synthesis. Keywords: Genotype comparison
2008-01-03 | GSE6642 | GEO
Project description:Genetic (animal species, breed and genotype) has a considerable effect on milk composition. In particular, goats present a remarkable polymorphism at the alpha-S1-casein (CSN1S1) locus which results in large differences in milk protein content and indirectly in milk fat content and its fatty acids composition. In order to decipher the mammary metabolic pathways involved, we examined the effect of CSN1S1 polymorphism on the expression of 8,379 genes in caprine mammary gland using a bovine oligonucleotide microarray. Six lactating goats fed ad libitum were assigned to 2 groups based on their genotype at the CSN1S1 locus: High vs. Low genotype goats carrying, respectively, two reference alleles associated with high CSN1S1 synthesis and two defective alleles associated with low CSN1S1 synthesis. Keywords: Genotype comparison
2008-01-03 | GSE6637 | GEO
Project description:A food deprivation affects the miRNome in the lactating goat mammary gland
| PRJNA260090 | ENA