Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Life-long persistence of nuclear RNAs in the mouse brain [NPCs]

ABSTRACT: Life-long persistence of nuclear RNAs in the mouse brain [NPCs]

PROVIDER: PRJNA1041774 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26862035_1.fastq.gz	Fastqsanger.gz
	SRR26862035_2.fastq.gz	Fastqsanger.gz
	SRR26862036_1.fastq.gz	Fastqsanger.gz
	SRR26862036_2.fastq.gz	Fastqsanger.gz
	SRR26862037_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Life-long persistence of nuclear RNAs in the mouse brain [NPCs]

Project description:Genomic DNA residing in the nuclei of mammalian neurons can be as old as the organism itself. The life span of non-coding nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. Here, we report the identification and characterization of nuclear RNAs that do not turn over for at least two years in the adult mouse brain. These long-lived RNAs (LL-RNA) are stably retained in nuclei in a neural cell type-specific manner and are required for the maintenance of heterochromatin. Thus, the remarkable life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information but also the extreme stability of RNA for the functional organization of chromatin.

2024-04-04 | GSE248099 | GEO

Life-long persistence of nuclear RNAs in the mouse brain

Project description:Life-long persistence of nuclear RNAs in the mouse brain

| PRJNA1041766 | ENA

Life-long persistence of nuclear RNAs in the mouse brain [Hippocampus]

Project description:Life-long persistence of nuclear RNAs in the mouse brain [Hippocampus]

| PRJNA1041775 | ENA

Life-long persistence of nuclear RNAs in the mouse brain [Hippocampus]

2024-04-04 | GSE248100 | GEO

Life-long persistence of nuclear RNAs in the mouse brain

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-04-04 | GSE248101 | GEO

Regulation of the ESC transcriptome by nuclear long non-coding RNAs

Project description:We performed poly(A)+ RNA sequencing (Illumina GAIIx) from nuclear and whole cell RNA fractions of mouse AB2.2 embryonic stem cells (ESCs) and neural progenitors (NPCs) differentiated from ESCs. We further transfected AB2.2 ESCs with control antisense oligonucleotides (ASOs), or 2 independent ASOs each targeting either PAT-14 lncRNA or Firre lncRNA for 24 hours, in 4 biological replicates each and performed poly(A)+ RNA sequencing (Illumina HiSeq 2000).

2015-12-01 | E-MTAB-3198 | biostudies-arrayexpress

Long read sequencing of nuclear RNAs from human coronary artery smooth muscle cells

Project description:To study isoforms of nuclear RNAs, including CARMN lncRNA, we performed Oxford Nanopore long-read sequencing of RNAs isolated from the nuclear fraction of human coronary artery smooth muscle cells.

2021-04-06 | GSE165445 | GEO

Regulation of nuclear transcription by mitochondrial RNAs

Project description:Regulation of nuclear transcription by mitochondrial RNAs

| PRJNA873067 | ENA

Regulation of the ESC transcriptome by nuclear long non-coding RNAs

Project description:Regulation of the ESC transcriptome by nuclear long non-coding RNAs

| PRJEB8090 | ENA

Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx

Project description:Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx

| PRJNA391572 | ENA