Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

ABSTRACT: Lineage-specific intolerance to oncogenic drivers restricts histological transformation

PROVIDER: PRJNA1042808 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26878800.fastq.gz	Fastqsanger.gz
	SRR26878801.fastq.gz	Fastqsanger.gz
	SRR26878802.fastq.gz	Fastqsanger.gz
	SRR26878803.fastq.gz	Fastqsanger.gz
	SRR26878804.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 60

Similar Datasets

Lineage-specific intolerance to oncogenic drivers restricts histological transformation [ATAC-Seq]

Project description:Lineage-specific intolerance to oncogenic drivers restricts histological transformation [ATAC-Seq]

| PRJNA1042809 | ENA

Lineage-specific intolerance to oncogenic drivers restricts histological transformation [scRNA-Seq]

Project description:Lineage-specific intolerance to oncogenic drivers restricts histological transformation [scRNA-Seq]

| PRJNA1042807 | ENA

Lineage-specific intolerance to oncogenic drivers restricts histological transformation [ATAC-Seq]

Project description:Lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC) are thought to originate from different epithelial cell types in the lung. Intriguingly, LUAD can histologically transform into SCLC following treatment with targeted therapies. Here we designed models to follow the conversion of LUAD to SCLC and found the barrier to histological transformation converges on tolerance to Myc, which we implicate as a lineage-specific driver of the pulmonary neuroendocrine cell. Histological transformations are frequently accompanied by activation of the Akt pathway. Manipulating this pathway permitted tolerance to Myc as an oncogenic driver, producing rare, stem-like cells, transcriptionally resembling the pulmonary basal lineage. These findings suggest histological transformation may require the plasticity inherent to the basal stem cell, enabling tolerance to previously incompatible oncogenic driver programs.

2024-01-01 | GSE248206 | GEO

Lineage-specific intolerance to oncogenic drivers restricts histological transformation [scRNA-Seq]

2024-01-01 | GSE248202 | GEO

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-01 | GSE248207 | GEO

Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

Project description:Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

| PRJNA725900 | ENA

miRNA profiling from different histological subtypes of colorectal carcinoma

Project description:Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological pathways and molecular drivers have been described and some of the associated markers are used to select effective anti-neoplastic therapy. This dataset is part of ColPortal, a platform that integrates transcriptomic, microtranscriptomic, methylomic and microbiota data of patients with colorectal cancer. ColPortal also includes information of histological features and digital histological slides from the study cases.

2019-08-23 | GSE136194 | GEO

Smc3 regulates B-cell transit through germinal centers and restricts their malignant transformation

Project description:Smc3 regulates B-cell transit through germinal centers and restricts their malignant transformation

| PRJNA601904 | ENA

microarray in SCLC transformation

Project description:The histological transformation of lung adenocarcinoma (LUAD) to an aggressive neuroendocrine (NE) derivative resembling SCLC is a signature example of lineage plasticity in cancer.But the changes of gene expression need to be studied. We used microarrays to detail the global programme of gene expression under transformation and reversed transformation cells and identified distinct classes of up-regulated genes during this process.

2024-06-12 | GSE242843 | GEO

Smc3 regulates B-cell transit through germinal centers and restricts their malignant transformation (HiC)

Project description:Smc3 regulates B-cell transit through germinal centers and restricts their malignant transformation (HiC)

| PRJNA601902 | ENA