Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [scRNA-seq]

ABSTRACT: Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [scRNA-seq]

PROVIDER: PRJNA1043218 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2

Project description:Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2

| PRJNA1051031 | ENA

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 II

Project description:Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 II

| PRJNA1050190 | ENA

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [RNA-seq]

Project description:Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [RNA-seq]

| PRJNA1051036 | ENA

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-12-25 | GSE249857 | GEO

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 II

Project description:The objective was to investigate the disparity in gene expression between IRG1+/+ BMDMs and IRG1-/- BMDMs following VSV infection.

2024-06-01 | GSE249683 | GEO

Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

Project description:Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

2023-11-08 | GSE221134 | GEO

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [RNA-seq]

Project description:The objective was to investigate the disparity in gene expression between DMSO-treated group and OI-treated group following VSV infection.

2024-12-25 | GSE249856 | GEO

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [scRNA-seq]

Project description:The purpose is to investigate alterations in gene expression across diverse cellular subsets within the pulmonary tissue of mouse infected with VSV.

2024-12-25 | GSE248329 | GEO

Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

Project description:Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

| PRJNA913089 | ENA

Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst

Project description:Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even in the setting of a robust neutrophil response, S. aureus can cause persistent infection. Here we demonstrate that S. aureus impairs neutrophil function by triggering the production of the anti-inflammatory metabolite, itaconate. The enzyme that synthesizes itaconate, Irg1, is selectively expressed in neutrophils during S. aureus pneumonia. Itaconate inhibits neutrophil glycolysis and oxidative burst, which impairs survival and bacterial killing. In a murine pneumonia model, neutrophil Irg1 expression protects critical lung cell populations from oxidative stress but compromises bacterial clearance. S. aureus is thus able to evade innate immune clearance by targeting neutrophil metabolism and inducing the production of the antiinflammatory metabolite itaconate.

2023-01-01 | GSE215195 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data