Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR26911986_1.fastq.gz | Fastqsanger.gz | |||
| SRR26911986_2.fastq.gz | Fastqsanger.gz | |||
| SRR26911987_1.fastq.gz | Fastqsanger.gz | |||
| SRR26911987_2.fastq.gz | Fastqsanger.gz | |||
| SRR26911988_1.fastq.gz | Fastqsanger.gz |
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Similar Datasets
Project description:Circular (circ) RNAs have been widely reported to be involved in gastric cancer (GC) pathogenesis and coiled coil domain containing 6 (CCDC6) is recognized as fused partner of multiple oncogenes; however, the underlying mechanisms of how circRNAs regulate CCDC6 expression in the progression and prognosis of GC remain unclear. Here, we discovered a novel circRNA derived from the DNA2 gene locus (circDNA2) through joint analysis of circRNA microarrays. By performing qRT-PCR and FISH assays with a human tissue microarray, circDNA2 was identified to be highly expressed in GC tissues and associated with lymphatic invasion of GC patients. Knockdown of circDNA2 suppressed the proliferation of GC cells by reducing CCDC6 expression in vitro. Mechanically, circDNA2 acted as a sponge for microRNA (miR)-149-5p, which was validated to target CCDC6 by dual luciferase reporter assays and rescue experiments. Both miR-149-5p low expression and CCDC6 high expression were related to unfavorable prognosis of GC patients. Moreover, GC patients with low miR-149-5p expression had shorter overall survival and higher risk of chemotherapy resistance compared with these with high miR-149-5p expression. In summary, our findings reveal that circDNA2 contributes to the growth and lymphatic metastasis of GC through upregulating CCDC6 expression via sponging miR-149-5p. The circDNA2/miR-149-5p/CCDC6 axis might be developed as a therapeutic target and prognostic indicator for GC patients.
2024-02-25 | GSE167512 | GEO
Project description:In the present study, we found that circADD2 was down-regulated in ALL tissues and cell lines. Overexpression of circADD2 inhibited cell proliferation and promoted apoptosis both in vitro and in vivo. Additionally, we found that miR-149-5p may increase the expression of the target gene AKT2 through the mechanism of RNAa, and the level of AKT2 can be reversed by circADD2. Briefly, circADD2 could directly sponge miR-149-5p to downregulate AKT2 expression.
2021-03-16 | GSE166579 | GEO
Project description:149 Neisseria meningitidis genomes
| PRJEB64202 | ENA
Project description:More then 10 million raw reads were acquiredIn total, 247 unique mature sequences which contain 149 conserved miRNA and 98 novel miRNAs were identified.
2018-12-01 | GSE107822 | GEO
Project description:modENCODE_submission_3703 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of 125 chromosomal proteins across the Drosophila melanogaster genome. The proteins under study are involved in basic chromosomal functions such as DNA replication, gene expression, gene silencing, and inheritance. We will perform Chromatin ImmunoPrecipitation (ChIP) using genomic tiling arrays. We will initially assay localizations using chromatin from three cell lines and two embryonic stages, and will then extend the analysis of a subset of proteins to four additional animal tissues/stages For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf EXPERIMENT TYPE: CHIP-chip. BIOLOGICAL SOURCE: Strain: mt2 mutant(official name : MT2 [149] mutant genotype : Mt2 [149]/Mt2 [149] outcross : unknown tags : Transposon description : Mobilization of the progenitor insertion P{EP}GE15695. 59bp of 5' P{EP} sequence are present at the transcriptional start site description : along with a 4bp duplication of coding sequences. The mutation results in a frameshift. Developmental Stage: 3rd Instar Larvae; Genotype: Mt2 [149]/Mt2 [149]; NUMBER OF REPLICATES: 4; EXPERIMENTAL FACTORS: Strain mt2 mutant(official name : MT2 [149] mutant genotype : Mt2 [149]/Mt2 [149] outcross : unknown tags : Transposon description : Mobilization of the progenitor insertion P{EP}GE15695. 59bp of 5' P{EP} sequence are present at the transcriptional start site description : along with a 4bp duplication of coding sequences. The mutation results in a frameshift. Antibody HP1 wa191 (target is HP1a); Developmental Stage 3rd Instar Larvae
2013-02-22 | E-GEOD-44477 | biostudies-arrayexpress
Project description:We genotyped 149 human surgical liver samples from Caucasian donors with detailed medical documentation. The overall purpose of the study was to identify expression quantitative trait loci (eQTL) in human liver.....
2012-07-03 | GSE39036 | GEO
Project description:149 unpaired initial tumor samples (133/149 FFPE and 16/149 fresh frozen samples) of lFL patients measured with OncoScan SNP microarrays, Affymetrix CEL intensity data file types (Thermo Fisher Scientific, Waltham, Massachusetts, USA)
| EGAD00010002593 | EGA
Project description:modENCODE_submission_3693 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of the major histone modifications across the Drosophila melanogaster genome. The modifications under study are involved in basic chromosomal functions such as DNA replication, gene expression, gene silencing, and inheritance. We will perform Chromatin ImmunoPrecipitation (ChIP) using genomic tiling arrays. We will initially assay localizations using chromatin from three cell lines and two embryonic stages, and will then extend the analysis of a subset of proteins to four additional animal tissues/stages. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf EXPERIMENT TYPE: CHIP-chip. BIOLOGICAL SOURCE: Strain: mt2 mutant(official name : MT2 [149] mutant genotype : Mt2 [149]/Mt2 [149] outcross : unknown tags : Transposon description : Mobilization of the progenitor insertion P{EP}GE15695. 59bp of 5' P{EP} sequence are present at the transcriptional start site description : along with a 4bp duplication of coding sequences. The mutation results in a frameshift. Developmental Stage: 3rd Instar Larvae; Genotype: Mt2 [149]/Mt2 [149]; NUMBER OF REPLICATES: 4; EXPERIMENTAL FACTORS: Strain mt2 mutant(official name : MT2 [149] mutant genotype : Mt2 [149]/Mt2 [149] outcross : unknown tags : Transposon description : Mobilization of the progenitor insertion P{EP}GE15695. 59bp of 5' P{EP} sequence are present at the transcriptional start site description : along with a 4bp duplication of coding sequences. The mutation results in a frameshift. Antibody H3K9me2-Ab2 (new lot) (target is H3K9me2); Developmental Stage 3rd Instar Larvae
2013-02-22 | E-GEOD-44470 | biostudies-arrayexpress