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Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells III

ABSTRACT: Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells III

PROVIDER: PRJNA1045603 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26965623_1.fastq.gz	Fastqsanger.gz
	SRR26965623_2.fastq.gz	Fastqsanger.gz
	SRR26965624_1.fastq.gz	Fastqsanger.gz
	SRR26965624_2.fastq.gz	Fastqsanger.gz
	SRR26965625_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells III

Project description:The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remains largely undefined. Here, we demonstrate that the neonatal gut is uniquely enriched with neurotransmitters, including serotonin; specific gut bacteria produce serotonin directly while downregulating monoamine oxidase A to limit serotonin breakdown. Serotonin directly signals to T cells to increase intracellular indole-3-acetaldehdye to inhibit mTOR activation and thereby promotes the differentiation of regulatory T cells, both ex vivo and in vivo in the neonatal intestine. Oral gavage of serotonin into neonatal mice leads to long-term T cell-mediated antigen-specific immune tolerance towards both dietary antigens and commensal bacteria. Together, our study has uncovered an important role for unique gut bacteria to increase serotonin availability in the neonatal gut and a novel function of gut serotonin to shape T cell response to dietary antigens and commensal bacteria to promote immune tolerance in early life.

2024-01-31 | GSE248692 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells II

2024-01-31 | GSE248691 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells I

2024-01-31 | GSE248690 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells

Project description:Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells

| PRJNA1045606 | ENA

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells I

Project description:Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells I

| PRJNA1045602 | ENA

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells II

Project description:Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells II

| PRJNA1045601 | ENA

Serotonin signals through a gut-liver axis to regulate hepatic steatosis

Project description:Purpose: While various functions of peripheral serotonin are known, the direct role of serotonin in regulating hepatic lipid metabolism in vivo is not well understood. We studied whether serotonin directly acts on liver to regulate lipid metabolism. Methods: Methods: 12 weeks aged liver-specific Htr2a KO (Albumin-Cre+/-; Htr2aflox/flox, herein named Htr2a LKO) mice and wildtype (WT) littermates were fed a high-fat diet (HFD, 60% fat calories) for 8 weeks. Results: Hepatic lipid droplet accumulation, NAFLD activity score, and hepatic triglyceride levels were dramatically reduced in HFD-fed Htr2a LKO mice compared to WT littermates. Conclusions: Gut-derived serotonin is a direct regulator of hepatic lipid metabolism via a gut TPH1-liver HTR2A endocrine axis. And shows promise as a novel drug target to ameliorate NAFLD with minimal systemic metabolic effects.

2018-11-27 | GSE120662 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-31 | GSE248694 | GEO

Carbohydrate Syntrophy enhances the establishment of Bifidobacterium breve UCC2003 in the neonatal gut

Project description:To extend our understanding of bifidobacterial mutualism and carbohydrate syntrophy in the gut we adopted advanced functional genomics to create single- and double-deletion isogenic strains of the NagA encoding genes of B. breve UCC2003. The resulting strains were examined, as compared to the parent strain, for their ability to metabolise particular host derived carbohydrates. In addition, the B. breve strains were examined for their crossfeeding capability and ability to establish, in the presence of B. bifidum ATCC29521, in the gut of dam fed neonatal mice.

2018-07-19 | GSE110077 | GEO

Differential response of polarized gut epithelial cells to type I and III interferon

Project description:Whereas most body cells respond to stimulation with type I (alpha and beta) interferon, type III (lambda) interferon was shown to specifically stimulate epithelial cells in the gastrointestinal and respiratory tract. Although both cytokines activate different receptor molecules (IFNAR versus IL-28R/IL-10R, respectively) the downstream signalling pathways and the ultimate response have been reported to be very similar. Here we examined the response of polarized gut intestinal epithelial cells to type I versus type III interferon in order to study potential differences in the transcriptional response.

2017-12-22 | GSE91382 | GEO

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