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Fusobacterium nucleatum subsp. nucleatum

ABSTRACT: Fusobacterium nucleatum subsp. nucleatum Raw sequence reads

PROVIDER: PRJNA1045796 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26963673_1.fastq.gz	Fastqsanger.gz
	SRR26963673_2.fastq.gz	Fastqsanger.gz
	SRR26963674_1.fastq.gz	Fastqsanger.gz
	SRR26963674_2.fastq.gz	Fastqsanger.gz
	SRR26963675_1.fastq.gz	Fastqsanger.gz

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RNA-seq of PBT2-Zn treated Fusobacterium nucleatum cells in vitro

Project description:To investigate the effect of the Zn ionophore, PBT2, on the transcriptomic response of Fusobacterium nucleatum ATCC 25586, RNA was extracted from bacterial samples which had been treated as follows: Untreated (0.006% DMSO v/v), DMSO-Zn treated (0.006% DMSO v/v + 200 uM ZnSO4), or PBT2-Zn treated (0.125 ug/mL PBT2 + 200 uM ZnSO4) (DMSO was the vehicle control). RNA samples were collected at 0h, 0.5h, and 1h post challenge in biological triplicate and sequenced using Illumina HiSeq platform. We mapped sequences to the reference genome F. nucleatum subsp. nucleatum ATCC 25586 and performed DEseq2 analysis to determine differentially expressed genes across time and treatment.

2021-07-15 | E-MTAB-8681 | biostudies-arrayexpress

Influence of dual-species coaggregation on transcriptional changes of Streptococcus gordonii and Fusobacterium nucleatum subsp. polymorphum

Project description:Interspecies coaggregation promotes transcriptional changes of oral bacteria, contributing to the development of structurally balanced biofilms as well as oral diseases such as periodontitis. Streptococcus gordonii (S. gordonii) is an early colonizer of the oral cavity, and Fusobacterium nucleatum (F. nucleatum) may act as a bridge adhering to both early and late oral colonizers. These two species were commonly detected in healthy and periodontitis-diseased oral sites and could interact with immune cells such as macrophages. However, little research explored how intergeneric coaggregation affected transcriptional changes in S. gordonii and F. nucleatum subsp. polymorphum and how these gene changes might affect both species’ pathogenicity. The present study investigated transcriptional changes of both species in response to dual-species physical association using dual RNA-seq. Results indicated that after 30-min dual-species coaggregation, 148 genes were significantly up-regulated, and 124 genes were significantly down-regulated in S. gordonii. A total of 154 genes were significantly down-regulated, and 10 genes were significantly up-regulated in F. nucleatum subsp. polymorphum. A majority of up-regulated S. gordonii genes were involved in the biosynthesis and export of cell-wall proteins and the pathway of carbohydrate metabolism, and a group of down-regulated S. gordonii genes were associated with fatty acid biosynthesis and peptidoglycan biosynthesis. The transcriptome profiles indicated that the interspecies coaggregation led to a reduced level of DNA repair and lipopolysaccharides virulence in F. nucleatum subsp. polymorphum. The present study revealed that dual-species coaggregation induced a wide array of gene changes in S. gordonii and F. nucleatum subsp. polymorphum, enhancing S. gordonii’s adherence ability and attenuating F. nucleatum subsp. polymorphum's ability to produce LPS.

2021-05-20 | GSE164282 | GEO

RNA landscape of the emerging cancer bug Fusobacterium nucleatum

Project description:Analysis of the region of interest for total protein samples or the outer membrane fraction of Fusobacterium nucleatum subsp. nucleatum ATCC 23726. The bacteria carried either an empty vector control, or a plasmid for the overexpression of the FoxI sRNA or its mutant version FoxI-3C.

2021-05-04 | PXD022474 | Pride

Fusobacterium nucleatum subsp. nucleatum

Project description:Fusobacterium nucleatum subsp. nucleatum ATCC 25586 Genome sequencing and assembly

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Effect of Fusobacterium nucleatum on human HUVEC cells

Project description:Localization of Fusobacterium nucleatum in the placenta may be associated with pregnancy complications including preeclampsia (PE), but its specific pathobiology is unknown. Our aim was to analyze the effect of Fusobacterium nucleatum on HUVEC cells to further elucidate placental dysfunction in the context of Fusobacterium nucleatum infestation.

2024-06-08 | GSE269085 | GEO

Fusobacterium nucleatum subsp. nucleatum ChDC F316

Project description:Genome sequencing of Fusobacterium nucleatum subsp. nucleatum KCOM 1322

| PRJNA270149 | ENA

Comparison of Fusobacterium Nucleatum stimulated and unstimulated neutrophils

Project description:Neutrophils are known to be stimulated by different periodontal bacteria to produce reactive oxygen species and cytokines. It is inportant to investigate the gene changes made by bacteria of importance, of which, for periodontal disease, fusobaterium nucleatum is one. we used microarrays to investigate gene experssion changes in peripheral blood neutrophils werwhich e stimulated with or with out Fusobacterium Nucleatum (10953). Neutrophils from periodonatlly healthy individuals (n=4) were isolated and stimulated for 3hrs with or without fusobaterium nucleatum (10953). RNA was then extracted from these and pooled before hybridization on Affymetrix microarrays

2010-07-20 | E-GEOD-20151 | biostudies-arrayexpress

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