Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecularly defined and functionally distinct subcircuits of the medial mammillary nucleus

ABSTRACT: Molecularly defined and functionally distinct subcircuits of the medial mammillary nucleus

PROVIDER: PRJNA1046024 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Molecularly defined and functionally distinct subcircuits of the medial mammillary nucleus

Project description:we dissectede the PV positive neurons and Drd2 positive neurons from transgene mouse brains for single-cell RNA sequencing (RNA-seq) We then performed gene expression profiling analysis using data obtained from RNA-seq.

2024-11-28 | GSE248796 | GEO

Expression data from medial vestibular nucleus neuronal subtypes of mouse

Project description:Medial vestibular nucleus (MVN) neurons were functionally classified by single-cell gene expression profiling. The transcriptional diversity across MVN neuronal subtypes was further examined by microarray analysis.

2019-11-15 | GSE55656 | GEO

Molecularly defined circuits for cardiovascular and cardiopulmonary control

Project description:Molecularly defined circuits for cardiovascular and cardiopulmonary control

| PRJNA816512 | ENA

Transcription profiling of mouse bed nucleus of the stria terminalis and medial preoptic area

Project description:The effect of photoperiod on gene expression was assessed in punch samples of the bed nucleus of the stria terminalis and medial preoptic area. Long day mice were housed in 16L:8D and short day mice were housed in 8L:16D. Experiment Overall Design: For the medial preoptic area, independent samples were collected from long day (n=3) and short day (n=3) mice. For the bed nucleus of the stria terminalis independent samples were collected from long day (n=3) and short day (n=2) mice.

2008-06-14 | E-GEOD-5795 | biostudies-arrayexpress

Transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of alcohol-preferring and nonpreferring rats

Project description:Animal models provide opportunity to study neurobiological aspects of human alcoholism. Changes in gene expression have been implicated in mediating brain function, including reward system and addiction. The current study aimed to identify novel genes that may underlie ethanol preference. Microarray analysis comparing gene expression in nucleus accumbens (NAc), hippocampus (HP) and prefrontal medial cortex (mPFC) was performed in two rat strains selected for extreme levels of ethanol preference - Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP). The identified candidate genes may underlie differential ethanol preference in rat model of alcoholism. This is analysis of 18 RNA samples, including 9 technical replicates. Two strains of rats selected for extreme levels of ethanol preference (low preferring WLP and high preferring WHP) were compared. Three brain areas (nucleus accumbens, prefrontal medial cortex and hippocampus) were studied. For each brain area, 6 RNA samples (including 3 technical replicates) were analyzed. Each RNA sample consist of of equal amounts of total RNA from 3 male rats. Comparisons: Nucleus accumbens of WHP vs. Nucleus accumbens of WLP; Prefrontal medial cortex of WHP vs. Prefrontal medial cortex of WLP; Hippocampus of WHP vs. Hippocampus of WLP. 3 biological replicates in each comparison.

2015-01-17 | E-GEOD-65064 | biostudies-arrayexpress

Morphological diversity of single neurons in molecularly defined cell types

Project description:Morphological diversity of single neurons in molecularly defined cell types

| PRJNA751758 | ENA

hESC- and hiPSC-derived Schwann cells are Molecularly and Functionally Equivalent

Project description:hESC- and hiPSC-derived Schwann cells are Molecularly and Functionally Equivalent

| PRJNA860642 | ENA

Molecularly defined circuits for cardiovascular and cardiopulmonary control

Project description:The sympathetic and parasympathetic nervous systems regulate the activities of internal organs, but the molecular and functional diversity of their constituent neurons and circuits remains largely unknown. Here we use retrograde neuronal tracing, single-cell RNA sequencing, optogenetics and physiological experiments to dissect the cardiac parasympathetic control circuit in mice. We show that cardiac-innervating neurons in the brainstem nucleus ambiguus (Amb) are comprised of two molecularly, anatomically and functionally distinct subtypes. The first, which we call ambiguus cardiovascular (ACV) neurons (approximately 35 neurons per Amb), define the classical cardiac parasympathetic circuit. They selectively innervate a subset of cardiac parasympathetic ganglion neurons and mediate the baroreceptor reflex, slowing heart rate and atrioventricular node conduction in response to increased blood pressure. The other, ambiguus cardiopulmonary (ACP) neurons (approximately 15 neurons per Amb) innervate cardiac ganglion neurons intermingled with and functionally indistinguishable from those innervated by ACV neurons. ACP neurons also innervate most or all lung parasympathetic ganglion neurons—clonal labelling shows that individual ACP neurons innervate both organs. ACP neurons mediate the dive reflex, the simultaneous bradycardia and bronchoconstriction that follows water immersion. Thus, parasympathetic control of the heart is organized into two parallel circuits, one that selectively controls cardiac function (ACV circuit) and another that coordinates cardiac and pulmonary function (ACP circuit). This new understanding of cardiac control has implications for treating cardiac and pulmonary diseases and for elucidating the control and coordination circuits of other organs.

2022-05-28 | GSE198709 | GEO

Identification of cell types in medial vestibular nucleus and their response to unilateral vestibular loss

Project description:We performed single-cell RNA-seq of mouse medial vestibular nucleus to reveal the cell diversity of this region.

2023-01-14 | GSE143701 | GEO

Grouped ensemble coding of behavioral states by combinations of molecularly defined cell types

Project description:Grouped ensemble coding of behavioral states by combinations of molecularly defined cell types

| PRJNA625041 | ENA