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Calcitonin gene-related peptide sustains CD8 T cell inflammatory reactions in drug -induced reactions

ABSTRACT: Calcitonin gene-related peptide sustains CD8 T cell inflammatory reactions in drug -induced reactions

PROVIDER: PRJNA1049746 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26993700_1.fastq.gz	Fastqsanger.gz
	SRR26993700_2.fastq.gz	Fastqsanger.gz
	SRR26993689_1.fastq.gz	Fastqsanger.gz
	SRR26993689_2.fastq.gz	Fastqsanger.gz
	SRR26993690_1.fastq.gz	Fastqsanger.gz

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Calcitonin gene-related peptide sustains CD8+ T cell inflammatory reactions in drug -induced reactions [scRNA-Seq]

Project description:Calcitonin gene-related peptide sustains CD8+ T cell inflammatory reactions in drug -induced reactions [scRNA-Seq]

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Calcitonin gene-related peptide sustains CD8 T cell inflammatory reactions in drug -induced reactions [CD8 Smart-seq]

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Calcitonin gene-related peptide sustains CD8 T cell inflammatory reactions in drug -induced reactions

Project description:This SuperSeries is composed of the SubSeries listed below.

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Calcitonin gene-related peptide sustains CD8+ T cell inflammatory reactions in drug -induced reactions [scRNA-Seq]

Project description:We investigated the differentiation pattern of CD8+ T cells from healthy controls and patients with SJS/TEN.

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Calcitonin gene-related peptide sustains CD8 T cell inflammatory reactions in drug -induced reactions [CD8 Smart-seq]

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Transcriptomics Changes of Calcitonin Gene-related Peptide in Mitigating Lipopolysaccharide-induced Septic Cardiomyopathy

Project description:Septic cardiomyopathy (SCM) is the predominant cause of death in sepsis patients with undefined mechanism to date. Our study analyzed RNA sequencing (RNA-seq) data from rat heart tissue to discover key targets and potential pharmacological actions of the calcitonin gene-related peptide (CGRP) against SCM. A lipopolysaccharide-induced SCM model was established in rats (LPS 10 mg/kg, intraperitoneal (i.p.)). Thereafter, the myocardial tissues from the three groups of rats (Ctrl group, LPS group, and CGRP group) (n=5) were extracted and underwent RNA-seq, followed by bioinformatics analyses. Our findings suggest a basis for finding potential targets for CGRP in the treatment of SCM.

2024-11-06 | GSE266124 | GEO

Calcitonin gene related peptide negatively regulates alarmin-driven type 2 innate lymphoid cell responses

Project description:Neuroimmune interactions have emerged as critical modulators of allergic inflammation, and type 2 innate lymphoid cells (ILC2s) are an important cell type for mediating these interactions. Here, we show that ILC2s expressed both the neuropeptide CGRP (Calcitonin Gene-Related Peptide) and its receptor. CGRP potently inhibited alarmin-driven type 2 cytokine production and proliferation by lung ILC2s both in vitro and in vivo. CGRP induced marked changes in ILC2 expression programs in vivo and in vitro, attenuating alarmin-driven proliferative and effector responses. A distinct subset of ILCs scored highly for a CGRP-specific gene signature after in vivo alarmin stimulation, suggesting CGRP regulated this response. Finally, we observed increased ILC2 proliferation and type 2 cytokine production and exaggerated responses to alarmins in mice lacking the CGRP receptor. Together, these data indicate that endogenous CGRP is a critical negative regulator of ILC2 responses in vivo.

2019-10-08 | GSE136154 | GEO

Transcriptomics Changes of Calcitonin Gene-related Peptide in Mitigating Lipopolysaccharide-induced Septic Cardiomyopathy

Project description:Transcriptomics Changes of Calcitonin Gene-related Peptide in Mitigating Lipopolysaccharide-induced Septic Cardiomyopathy

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Sensory neurons expressing calcitonin gene-related peptide regulate adaptive thermogenesis and diet-induced obesity

Project description:Sensory neurons expressing calcitonin gene-related peptide regulate adaptive thermogenesis and diet-induced obesity

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Calcitonin gene related peptide negatively regulates alarmin-driven type 2 innate lymphoid cell responses

Project description:Calcitonin gene related peptide negatively regulates alarmin-driven type 2 innate lymphoid cell responses

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