Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MicroRNAs expression in vulvar lichen sclerosus keratinocytes and fibroblasts: further evidence and possible pathogenetic implications from an observational study

ABSTRACT: MicroRNAs expression in vulvar lichen sclerosus keratinocytes and fibroblasts: further evidence and possible pathogenetic implications from an observational study

PROVIDER: PRJNA1050173 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27145014.fastq.gz	Fastqsanger.gz
	SRR27145015.fastq.gz	Fastqsanger.gz
	SRR27145016.fastq.gz	Fastqsanger.gz
	SRR27145017.fastq.gz	Fastqsanger.gz
	SRR27145018.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 19

Similar Datasets

MicroRNAs expression in vulvar lichen sclerosus keratinocytes and fibroblasts: further evidence and possible pathogenetic implications from an observational study

Project description:It seems established that genetic and epigenetic determinants drive the multifactorial pathogenic processes in vulvar lichen sclerosus (VLS). Aberrant expression of microRNAs (miRNAs) has been observed in a few studies suggesting potential involvement. We aimed to assess the expression of miRNAs both in VLS and in healthy keratinocytes and fibroblasts cultured separately. The differential analysis led to the identification of 171 and 111 microRNAs with an expression difference of at least 1.5-fold between VLS and healthy samples, in keratinocytes and fibroblasts, respectively. More than 80% of the 111 microRNAs identified as differentially expressed in fibroblasts were also found to be differentially expressed in keratinocytes. A number of dysregulated miRNAs are involved in inflammation and fibrotic processes, namely miR-10a-5p and 3p, miR-143-3p and 5p, miR-181a-5p and 3p, miR-181b-5p and 3p, miR-21-3p, miR-146b-5p and miR-29c. Our results showed a clear separation of VLS keratinocytes and fibroblasts from healthy cells in terms of miRNA expression. It is noteworthy that the most dysregulated miRNAs are implicated in inflammatory and fibrotic pathways. It is conceivable that miRNA expression is functional in regulating pathogenetic mechanisms of LS.

2023-12-13 | GSE249675 | GEO

CHDR2007 Vulvar Premalignancies

Project description:The vulvar microbiome in lichen sclerosus and high-grade intraepithelial lesions

| PRJEB61325 | ENA

microRNA expression in vulvar melanoma

Project description:microRNA expression in RNA isolated from formalin fixed, paraffin embedded tissue from vulvar melanoma compared to primary cutaneous melanoma

2022-07-16 | GSE208174 | GEO

mRNA expression in vulvar melanoma

Project description:mRNA expression in RNA isolated from formalin fixed, paraffin embedded tissue from vulvar melanoma compared to primary cutaneous melanoma.

2022-07-16 | GSE208172 | GEO

Whole-genome shallow-sequencing of HPV-positive and HPV-negative vulvar lesions

Project description:Identification of copy number alterations of HPV-positive and HPV-negative vulvar squamous cell carcinomas (VSCC) and vulvar intraepithelial neoplasias (VIN), with special focus on VIN with and without VSCC, the latter group being defined as VIN with no VSCC development during >10 year follow-up.

2018-07-01 | E-MTAB-6113 | biostudies-arrayexpress

microRNA expression in vulvar melanoma

Project description:microRNA expression in vulvar melanoma

| PRJNA858651 | ENA

mRNA expression in vulvar melanoma

Project description:mRNA expression in vulvar melanoma

| PRJNA858658 | ENA

Expression data from Vulvar, Cervical, Endometrial Carcinoma tissue

Project description:A growing number of studies on gynecological cancers (GCs) have revealed potential gene markers associated either with the pathogenesis and progression of the disease on representing putative targets for therapy and treatment of cervical (CC), endometrial (EC) and vulvar cancer (VC). However, quite a little overlap is found between these data. In this study we combined data from the three GCs integrating gene expression profile analysis. The meta-analysis including our results and data emerge from other available studies on gynecological malignancies and other cancer types, revealed common properties among them including deregulation of cell cycle, immune response, antiviral response and apoptosis. Total RNA was extracted from physiological and cancer patients from cervix, endometrium and vulvar tissue and was hybridized on Affymetrix HG133_A_2.0 microarray chips corresponding to more than 12.000 uniquely represented genes. A total of 35 samples were used to identify potential biomarkers and signatures in each type of cancer.

2015-07-26 | E-GEOD-63678 | biostudies-arrayexpress

Project description:Skin and vaginal microbiomes in vulvar lichen sclerosus

| PRJNA987142 | ENA

UNCOVERING VULVAR CARCINOMA: AN INTEGRATIVE APPROACH

Project description:UNCOVERING VULVAR CARCINOMA: AN INTEGRATIVE APPROACH

| PRJNA343113 | ENA