Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation

ABSTRACT: Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation

PROVIDER: PRJNA1050209 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation II

Project description:Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation II

| PRJNA1050223 | ENA

Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation I

Project description:Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation I

| PRJNA1050221 | ENA

Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation I

Project description:53 tumors used in the clinical training and validation of a CUP machine learning classifier using methylation profiling

2025-01-15 | GSE249688 | GEO

Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation II

Project description:53 tumors used in the clinical training and validation of a CUP machine learning classifier using methylation profiling

2025-01-15 | GSE249711 | GEO

Expression analysis of cancer of unknown primary (CUP) 1

Project description:Biopsies (lymph nodes, ascites or hydrothorax) from 60 patients with cancer of unknown primary origin were analyzed. Results provide insight into the molecular pathogenesis of CUP.

2012-11-20 | GSE42392 | GEO

Expression analysis of cancer of unknown primary (CUP) 2

2019-01-31 | GSE125908 | GEO

Expression analysis of cancer of unknown primary (CUP)

2012-11-20 | E-GEOD-42392 | biostudies-arrayexpress

Accurate Identification of Sites of Origin in Carcinoma of Unknown Primary (CUP) Tumors Using DNA Methylation

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-01-15 | GSE249712 | GEO

Cancers of unknown primary (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin.

Project description:Employing genome wide transcriptome analysis,Linear Discriminant Analysis (LDA) and Quadratic Discriminant Analysis (QDA), we created a successful classification model to identify the putative origin of a CUP. Using the classifications of the CUPs enable the comparison of transcriptome profiles from CUPs to the equivalent normal metastasis across the different carcinoma types. Gene Set Enrichment Analysis (GSEA) and Pathway analysis were used to reveal the common biological features characterizing CUPs. The classifier was build using 2208 samples of normal tissue, known primary tumors, metastasis of known origin and tested on 60 CUP samples. 130 of these samples were collected and analyzed as part of the project and submitted to ArrayExpress. The analyses show that CUPs are distinct from metastases of known origin. CUPs exhibit inconsistent expression of conventional cancer biomarkers and QDA derived outlier scores show that CUPs are more distantly related to their primary tumor class than corresponding metastases of known origin. Gene set enrichment analysis showed that CUPs display increased expression of genes involved in DNA damage repair and by employing signatures of chromosome instability (CIN), we found that CUPs are chromosome unstable compared to metastases of known origin.

2015-05-31 | E-MTAB-3222 | biostudies-arrayexpress

Expression analysis of cancer of unknown primary (CUP)

Project description:Expression analysis of cancer of unknown primary (CUP)

| PRJNA517939 | ENA