Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (MeRIP-Seq)

ABSTRACT: N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (MeRIP-Seq)

PROVIDER: PRJNA1050277 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer

Project description:N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer

| PRJNA1050279 | ENA

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (MeRIP-Seq)

Project description:Our study examines the role of m6A RNA modification in regulating gene expression of transcripts promoting enzalutamide resistance in prostate cancer.

2024-05-01 | GSE249748 | GEO

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (RNA-seq)

Project description:N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (RNA-seq)

| PRJNA1050281 | ENA

Widespread N6-methyladenosine-dependent RNA Structural Switches Regulate RNA-Protein Interactions

Project description:We show that N6-methyladenosine (m6A), the most abundant internal modification in mRNA/lncRNA with still poorly characterized function, alters RNA structure to facilitate the access of RBM for heterogeneous nuclear ribonucleoprotein C (hnRNP C). We term this mechanism m6A-switch. Through combining PAR-CLIP with Me-RIP, we identify 39,060 m6A-switches among hnRNP C binding sites transcriptome-wide. We show that m6A-methyltransferases METTL3 or METTL14 knockdown decreases hnRNP C binding at 16,582 m6A-switches. Taken together, 2,798 m6A-switches of high confidence are identified to mediate RNA-hnRNP C interactions and affect diverse biological processes including cell cycle regulation. These findings reveal the biological importance of m6A and provide insights into the sophisticated regulation of RNA-RBP interactions through m6A-induced RNA structural remodeling. Measure the m6A methylated hnRNP C binding sites transcriptome-wide by PARCLIP-MeRIP; measure the differential hnRNP C occupancies upon METTL3/METTL14 knockdown by PAR-CLIP; measure RNA abundance and splicing level changes upon HNRNPC, METTL3 and METTL14 knockdown

2015-02-27 | E-GEOD-56010 | biostudies-arrayexpress

N6-Methyladenosine Modification Controls Circular RNA Immunity.

Project description:N6-Methyladenosine Modification Controls Circular RNA Immunity.

| PRJNA476784 | ENA

METTL14-mediated N6-methyladenosine modification of Col17a1/Itgα6/Itgβ4 governs epidermal homeostasis [MeRIP-seq]

Project description:METTL14-mediated N6-methyladenosine modification of Col17a1/Itgα6/Itgβ4 governs epidermal homeostasis [MeRIP-seq]

| PRJNA1034055 | ENA

N6-methyladenosine RNA modification is associated with enzalutamide resistance in prostate cancer (RNA-seq)

Project description:Our study examines the role of m6A RNA modification in regulating gene expression of transcripts promoting enzalutamide resistance in prostate cancer.

2024-05-01 | GSE249749 | GEO

N6-methyladenosine RNA methylome analyses in human prostate cell lines.

Project description:To identify N6-methyladenosine RNA methylome in human prostate cell lines, MeRIP-seq of RWPE-1 and LNCaP were performed.

2021-08-11 | GSE147885 | GEO

N6-Methyladenosine RNA Modification Regulates the Differential Muscle Development in Large White and Ningxiang Pigs

Project description:N6-methyladenosine (m6A) is the most common modification in eukaryotic RNAs. Accumulating evidence has shown that m6A methylation plays a vital role in various biological processes. However, research on the role of m6A modifications in regulation of porcine muscle growth is lacking. In this study, we identified differentially expressed genes in the early stages of muscle development between Large White (LW) and NingXiang (NX) pigs and further reported m6A methylation patterns via MeRIP-seq. We found that m6A modification regulates muscle cell development, myofibrils, cell cycle, and phosphatase regulator activity during the neonatal phase of muscle development. Interestingly, differentially expressed genes in LW and NX pigs were mainly enriched in pathways involved in protein synthesis. Furthermore, we performed a conjoint analysis of MeRIP-seq and RNA-seq data, and identified 27 differentially expressed and m6A-modified genes.

2024-05-06 | GSE266121 | GEO

FTO suppresses cardiac fibrosis after myocardial infarction via m6A-mediated epigenetic modification [MeRIP-seq]

Project description:Cardiac fibrosis is common in cardiovascular diseases. N6-methyladenosine (m6A) is one of the most common modifications in eukaryotic mRNAs. Previous research has suggested that m6A modification is vital in cardiovascular diseases. The underlying targets of FTO were selected through transcriptome sequencing (RNA-seq) combined with methylated RNA immunoprecipitation sequencing (MeRIP-seq). According to MeRIP-seq and RNA-seq, FTO inhibited collagen synthesis in CFs.

2024-03-03 | GSE259328 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data