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Aeromonas caviae

ABSTRACT: Analysis of global Aeromonas caviae genomes revealed that strains carrying T6SS are more common in human gastroenteritis than in environmental sources and are often phylogenetically related

PROVIDER: PRJNA1050808 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR28209323_1.fastq.gz	Fastqsanger.gz
	SRR28209323_2.fastq.gz	Fastqsanger.gz
	SRR28209324_1.fastq.gz	Fastqsanger.gz
	SRR28209324_2.fastq.gz	Fastqsanger.gz

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Project description:Aeromonas caviae has been associated with human gastrointestinal disease. Strains of this species typically lack virulence factors (VFs) such as enterotoxins and hemolysins that are produced by other human pathogens of the Aeromonas genus. Microarray profiling of murine small intestinal extracts, 24 hours after oral infection with an A. caviae strain, provides evidence of a Th1 type immune response. A large number of gamma-interferon (γ-IFN) induced genes are up-regulated as well as several tumor necrosis factor-alpha (TNF-α) transcripts. A. caviae has always been considered an opportunistic pathogen because it lacks obvious virulence factors. This current effort suggests A. caviae colonizes murine intestinal tract and causes what has been described by others as a dysregulatory cytokine response leading to an irritable bowel-like syndrome. This response would explain why a number of diarrheal waterborne outbreaks have been attributed to A. caviae even though it lacks obvious enteropathogenic properties. Keywords: Aeromonas caviae, infection, disease mechanism, TH1 resposne

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