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Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2

ABSTRACT: Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2

PROVIDER: PRJNA1051031 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26894805_1.fastq.gz	Fastqsanger.gz
	SRR26894805_2.fastq.gz	Fastqsanger.gz
	SRR26894806_1.fastq.gz	Fastqsanger.gz
	SRR26894806_2.fastq.gz	Fastqsanger.gz
	SRR27173423.fastq.gz	Fastqsanger.gz

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Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 II

Project description:Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 II

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Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [RNA-seq]

Project description:Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [RNA-seq]

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Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [scRNA-seq]

Project description:Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [scRNA-seq]

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Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-12-25 | GSE249857 | GEO

Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 II

Project description:The objective was to investigate the disparity in gene expression between IRG1+/+ BMDMs and IRG1-/- BMDMs following VSV infection.

2024-06-01 | GSE249683 | GEO

Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

Project description:Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

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Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [RNA-seq]

Project description:The objective was to investigate the disparity in gene expression between DMSO-treated group and OI-treated group following VSV infection.

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Neutrophils-derived itaconate facilitates viral infection via alkylating GDI2 [scRNA-seq]

Project description:The purpose is to investigate alterations in gene expression across diverse cellular subsets within the pulmonary tissue of mouse infected with VSV.

2024-12-25 | GSE248329 | GEO

Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane.

Project description:Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune response and pathogen infection. However, its involvement in viral infection and underlying mechanisms remain incompletely understood. Here, we demonstrate that the IRG1-itaconate axis facilitates the infections of VSV and IAV in macrophages and epithelial cells via Rab GTPases redistribution. Mechanistically, itaconate promotes the retention of Rab GTPases on the membrane via directly alkylating Rab GDP dissociation inhibitor beta (GDI2), the latter of which extracts Rab GTPases from the membrane to the cytoplasm. Multiple alkylated residues by itaconate, including cysteines 203, 335, and 414 on GDI2, were found to be important during viral infection. Additionally, this effect of itaconate needs an adequate distribution of Rab GTPases on the membrane, which relies on Rab geranylgeranyl transferase (GGTase-II)-mediated geranylgeranylation of Rab GTPases. The single-cell RNA sequencing data revealed high expression of IRG1 primarily in neutrophils during viral infection. Co-cultured and in vivo animal experiments demonstrated that itaconate produced by neutrophils plays a dominant role in promoting viral infection. Overall, our study reveals that neutrophils-derived itaconate facilitates viral infection via redistribution of Rab GTPases, suggesting potential targets for antiviral therapy.

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Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

Project description:Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

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