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Extraembryonic gut endoderm cells undergo programmed cell death during development

ABSTRACT: Extraembryonic gut endoderm cells undergo programmed cell death during development

PROVIDER: PRJNA1051994 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22817877_1.fastq.gz	Fastqsanger.gz
	SRR22817877_2.fastq.gz	Fastqsanger.gz
	SRR22817878_1.fastq.gz	Fastqsanger.gz
	SRR22817878_2.fastq.gz	Fastqsanger.gz
	SRR27199100_1.fastq.gz	Fastqsanger.gz

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Extraembryonic gut endoderm cells undergo programmed cell death during development (RRBS)

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Project description:Despite a distinct developmental origin, extraembryonic cells in mice contribute to gut endoderm and converge to transcriptionally resemble their embryonic counterparts. Notably, extraembryonic progenitors share a non-canonical epigenome, raising several pertinent questions, including whether this landscape is reset to match the embryonic regulation and if these cells persist into later development. Here, we developed a two-color lineage tracing strategy to track and isolate extraembryonic cells over time. We find that extraembryonic gut cells display substantial memory of their developmental origin including retention of their original DNA methylation landscape and resulting transcriptional signatures. Furthermore, we show that extraembryonic gut cells undergo programmed cell death and neighboring embryonic cells clear their remnants via non-professional phagocytosis. By midgestation, we no longer detect extraembryonic cells in the wild type gut while they persist and differentiate further in p53 mutant embryos. Our study provides key insights into the molecular and developmental fate of extraembryonic cells inside the embryo.

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Extraembryonic gut endoderm cells undergo programmed cell death during development (scRNA-seq)

Project description:Extraembryonic gut endoderm cells undergo programmed cell death during development (scRNA-seq)

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RNA-seq of H9 cell line during differentiation from naïve extraembryonic endoderm to extraembryonic mesoderm.

Project description:Extraembryonic mesoderm (ExM) is one of the first cell types that emerges during embryogenesis and constitutes essential supportive tissues for the pregnancy. Primate ExM is known to form prior to gastrulation, unlike its murine counterpart which is derived from the primitive streak. Based on the embryonic morphology and the proximity of ExM to the extraembryonic endoderm (hypoblast), we hypothesised that ExM can be derived in vitro from the naïve extraembryonic endoderm (nEnd) cell line. We applied a mesoderm differentiation protocol, which has been reported to induce ExM from mouse epiblast stem cells, on human nEnd and analysed the transcriptome on day 0, 1, 2, 8 and 15.

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