Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification [CUT&RUN]

ABSTRACT: Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification [CUT&RUN]

PROVIDER: PRJNA1052604 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification

Project description:Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification

| PRJNA1052602 | ENA

Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification [RNA-seq]

Project description:Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification [RNA-seq]

| PRJNA1052607 | ENA

Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification [CUT&RUN]

Project description:Embryos, originating from fertilized eggs, undergo continuous cell division and differentiation, accompanied by dramatic changes in transcription, translation, and metabolism. Epigenetic information and transcription factors (TFs) play indispensable roles in regulating these processes. Recently, the trophoblast regulator TFAP2C was identified as crucial in initiating early cell fate decisions. However, Tfap2c transcripts persist in both the inner cell mass (ICM) and trophectoderm (TE) of blastocysts, prompting inquiry into its function in post-lineage establishment. In this study, we delineate the dynamics of TFAP2C during the mouse peri-implantation stage and elucidate its collaboration with the key lineage regulators CDX2 and NANOG. Importantly, we propose that de novo formation of H3K9me3 in the extraembryonic ectoderm during implantation antagonizes TFAP2C binding to crucial developmental genes, thereby maintaining its lineage identity. Together, this research highlights the plasticity of the epigenetic environment in designating the genomic binding of highly adaptable lineage-specific TFs and regulating embryonic cell fates.

2024-04-01 | GSE250176 | GEO

Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-04-01 | GSE250178 | GEO

Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification [RNA-seq]

Project description:Embryos originate from fertilized eggs and are shaped through continuous cell division and differentiation, accompanied by dramatic changes in transcription, translation, and metabolism. Epigenetic information and transcription factors (TFs) play indispensable roles in regulating these processes. Recently, the trophoblast regulator TFAP2C was found to be essential in initiating the earliest cell fate decisions. However, Tfap2c transcripts are still detectable in both the inner cell mass (ICM) and trophectoderm (TE) of blastocysts, raising questions regarding how TFAP2C functions once these two lineages are established. In this study, we delineated the dynamics of TFAP2C during the mouse peri-implantation stage and elucidated its collaboration with the key lineage regulators CDX2 and NANOG. Importantly, we proposed that de novo formation of H3K9me3 in the extraembryonic ectoderm during implantation antagonizes TFAP2C binding to crucial developmental genes, thereby maintaining its lineage identity. Together, this research highlights the plasticity of the epigenetic environment in designating the genomic binding of highly adaptable lineage-specific TFs and regulating embryonic cell fates.

2024-04-07 | GSE250177 | GEO

H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development.

Project description:H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development.

| PRJNA898276 | ENA

PAX6D instructs neural retinal specification from human embryonic stem cell-derived neuroectoderm

Project description:PAX6D instructs neural retinal specification from human embryonic stem cell-derived neuroectoderm

| PRJNA526532 | ENA

H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development [RNA-seq]

Project description:H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development [RNA-seq]

| PRJNA898283 | ENA

H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development [ChIP-seq]

Project description:H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development [ChIP-seq]

| PRJNA898281 | ENA

Ablation of cDC2 specification by triple mutations in the Zeb2 enhancer [CUT&RUN]

Project description:Ablation of cDC2 specification by triple mutations in the Zeb2 enhancer [CUT&RUN]

| PRJNA779044 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data