Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs

ABSTRACT: Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs

PROVIDER: PRJNA1053808 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR27238864_1.fastq.gz	Fastqsanger.gz
	SRR27238864_2.fastq.gz	Fastqsanger.gz
	SRR27238865_1.fastq.gz	Fastqsanger.gz
	SRR27238865_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 25

Similar Datasets

Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [Visium]

Project description:Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [Visium]

| PRJNA1053812 | ENA

Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [scATAC-Seq]

Project description:Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [scATAC-Seq]

| PRJNA1053810 | ENA

Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [scRNA-seq]

Project description:Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [scRNA-seq]

| PRJNA1053811 | ENA

Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [Visium]

Project description:Fibrosis, the replacement of healthy tissue with collagen-rich matrix, can occur following injury in almost every organ. Mouse lungs follow stereotyped sequences of fibrogenesis-to-resolution after bleomycin injury, and we reasoned that profiling post-injury histological progression could uncover pro- vs. anti-fibrotic features with functional value for human fibrosis. We mapped spatiotemporally-resolved transformations in lung extracellular matrix (ECM) architecture to spatially-resolved, multi-omic data. First, we charted stepwise trajectories of matrix aberration vs. resolution using unsupervised machine learning, denoting a reversible transition in uniform-to-disordered histological architecture. Single-cell sequencing along these trajectories identified temporally-enriched “ECM-secreting” (Csmd1+) and “pro-resolving” (Cd248+) fibroblasts, for which Visium inferred divergent histological signatures and spatial-transcriptional “neighborhoods”. Critically, pro-resolving fibroblast instillation helped ameliorate fibrosis in vivo. Further, fibroblast neighborhood-associated moieties, Serpine2 and Pi16, functionally modulated human lung fibrosis ex vivo. Spatial phenotyping of idiopathic pulmonary fibrosis further uncovered analogous fibroblast subtypes and neighborhoods in human disease. Collectively, these findings establish an atlas of pro-/anti-fibrotic factors underlying lung matrix architecture and implicate fibroblast-centered moieties in modulating fibrotic progression vs. resolution.

2025-01-07 | GSE250395 | GEO

Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [scRNA-seq]

2025-01-07 | GSE250396 | GEO

Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs [scATAC-Seq]

2025-01-07 | GSE250397 | GEO

Histological Signatures Reveal Anti-Fibrotic Factors in Mouse and Human Lungs

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-01-07 | GSE250398 | GEO

Gene expression signatures for Normal-looking, fibrotic foci and hyperplastic (adjacent to fibrotic foci) area in IPF lungs

Project description:To further understand the pathologic microenvironment in IPF, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish normal and IPF lung in normal-looking, fibrotic foci and hyperplastic areas of IPF lung. Four IPF lungs were dissected into normal-looking, fibrotic foci and hyperplastic areas by Laser-Capture-Microdissection. Gene expression analysis showed that 638 significantly different genes were identified that clearly distinguished the different IPF microenvironments . Among them, MMP19 was revealed as one of the most significantly up-regulated genes that distinguished normal looking epithelial cells (N) to hyperplastic epithelial cells, MMP19 up-regulation in IPF lungs was verified by immunohistochemical (IHC), qRT-PCR and Western-blot. IPF lungs are heterogeneity complex, which comprise normal looking area, fibrotic foci and hyperplastic area. In this study we separated the normal, fibrotic foci and hyperplastic area by LCM and employed Agilent whole genome gene expression microarray profiling to identify genes with the potential to distinguish the unique microenironment of IPF

2013-01-11 | E-GEOD-35309 | biostudies-arrayexpress

Gene expression signatures for Normal-looking, fibrotic foci and hyperplastic (adjacent to fibrotic foci) area in IPF lungs

2013-01-11 | GSE35309 | GEO

Genome-wide analysis of gene expression in normal and fibrotic mouse kidneys and normal and fibrotic mouse lungs

Project description:In this study, adult virgin female BALB/C mice were kidney and lungs were harvested for RNA extraction (healthy kidney and lung). Adult virgin female BALB/C mice were subjected to unilateral ureter obstruction (UUO) to induce kidney fibrosis and the fibrotic kidney was harvested for RNA extraction. Adult virgin female BALB/C mice were subjected to intratracheal administration of bleomycine to induce lung fibrosis and the fibrotic lungs was harvested for RNA extraction.

2020-04-07 | GSE97546 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data