Project description:Darier disease (DD) is a rare, inherited multi-organ disorder associated with mutations in the ATP2A2 gene. In DD patients, the skin is frequently affected, characterized by malodorous, inflamed skin and recurrent, severe infections. Therapeutic options are limited and inadequate for the long-term management of this chronic disease. Using immunoprofiling with NanoString technology we demonstrate enhanced expression of Th-17-related genes and cytokines in five DD patients. We prove that targeting the IL-23/-17 axis in DD with monoclonal antibodies is an effective and safe therapy in DD patients, leading also to significant clinical improvement.

2023-09-23 | GSE222043 | GEO

Immunoprofiling of mouse prostate cancer infiltrate

Project description:Immunoprofiling of mouse prostate cancer infiltrate

| PRJNA958227 | ENA

miR-Blood - a small RNA sequencing atlas of purified human blood components

Project description:miR-Blood - a small RNA sequencing atlas of purified human blood components

| PRJNA937741 | ENA

miR-Blood - a small RNA sequencing atlas of purified human blood components

Project description:miR-Blood is a high-quality, small RNA expression atlas for the major components of human peripheral blood (plasma, erythrocytes, thrombocytes, monocytes, neutrophils, eosinophils, basophils, natural killer cells, CD4+ T cells, CD8+ T cells, and B cells). *** The data provided in this GEO dataset is licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ***

2024-01-16 | GSE225872 | GEO

A Cell Atlas of Microbe-Responsive Processes in the Zebrafish Intestine

Project description:A Cell Atlas of Microbe-Responsive Processes in the Zebrafish Intestine

| PRJNA679624 | ENA

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling

Project description:Covid Immunoprofiling

| PRJEB57300 | ENA