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Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice

ABSTRACT: Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice

PROVIDER: PRJNA1055010 | ENA |

REPOSITORIES: ENA

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Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice [RNA-seq]

Project description:Mammals adaptively regulate energy metabolism in response to environmental changes such as starvation and cold circumstances. Thioredoxin-interacting protein (Txnip), known as a redox regulator, serves as a nutrient sensor regulating energy homeostasis. Txnip is essential for mice to adapt to starvation, but its role in adapting to cold circumstances remains unclear. Here, we identified Txnip as a pivotal factor for maintaining non-shivering thermogenesis in mice. Txnip protein levels in brown adipose tissue (BAT) were upregulated by the acute cold exposure. Txnip-deficient (Txnip-/-) mice acclimated to thermoneutrality (30°C) exhibited significant BAT enlargement and triglyceride accumulation with downregulation of BAT signature and metabolic gene expression. Upon acute cold exposure (5°C), Txnip-/- mice showed a rapid decline in BAT surface temperatures with the failure of increasing metabolic respiration, developing lethal hypothermia. The BAT dysfunction and cold susceptibility in Txnip-/- mice were corrected by acclimation to 16°C, protecting the mice from life-threatening hypothermia. Transcriptomic and metabolomic analysis using dissected BAT revealed that despite preserving glycolysis, the BAT of Txnip-/- mice failed to activate the catabolism of branched-chain amino acids and fatty acids in response to acute cold stress. These findings illustrate that Txnip is required for maintaining basal BAT function and ensuring cold-induced thermogenesis.

2025-01-01 | GSE251656 | GEO

Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice [ChIP-seq]

2025-01-01 | GSE251653 | GEO

Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice [RNA-seq]

Project description:Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice [RNA-seq]

| PRJNA1055025 | ENA

Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice [ChIP-seq]

Project description:Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice [ChIP-seq]

| PRJNA1055026 | ENA

Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-01-01 | GSE251657 | GEO

TXNIP loss

Project description:TXNIP loss

| PRJNA923024 | ENA

Cold-induction of Afadin in Brown Fat supports its thermogenic capacity

Project description:Transcriptomic analysis of brown fat from fat-specific Afadin depleted mice either at thermoneutrality or after 6 houts of cold exposure (5 degree celsius)

2021-05-12 | GSE147392 | GEO

DNA methylation alternations in the offspring brown adipose tissue from high fat diet dams

Project description:Maternal high fat diet may disturb susceptibility in offspring. Brown adipose tissue from maternal high fat diet has CpG sites that exhibit differential DNA methylationregulated compared to control.

2021-07-26 | GSE173218 | GEO

Transcriptome analysis of brown fat in young or old mice in cold exposure

Project description:Purpose: We investigated the transcriptomic change in brown fat of young and old mice (wild type) through high-throughput RNA-sequencing (RNA-Seq) analysis when the mice were exposed to cold room or room temperatur. Methods: We prepared 10 of young (3 months) mice and 9 of old (24 months) mice, and kept them in cold room (4°c) or room temperature (24°c) for 24 hours. Then, we sacrified mice and extracted RNA from brown fat tissue (BAT) for RNA-seq experiment. Results: BAT of Young mice showed increased carbohydrate metabolism and glycolytic flux during cold exposure Conclusions: The thermogenesis function of BAT is accelerated on cold exposure.

2020-07-31 | GSE135391 | GEO

A BAT-enriched RNA binding protein, Ybx2, regulates cold-induced brown fat activation by stabilizing Pgc1α mRNA

Project description:To study the role of Ybx2 in brown fat activity, we performed the RNA-seq data for wildtype and Ybx2 knockout brown fat under room temperature and upon cold exposure as well as for wildtype and Ybx2 knockout brown adipocytes culture from stromal vascular fraction cells. To determine the targets of Ybx2, we performed RNA immunopercipitatoin followed by RNA-seq

2019-08-23 | GSE86590 | GEO

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