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Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins

ABSTRACT: Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins

PROVIDER: PRJNA1055032 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27297328_1.fastq.gz	Fastqsanger.gz
	SRR27297328_2.fastq.gz	Fastqsanger.gz
	SRR27297329_1.fastq.gz	Fastqsanger.gz
	SRR27297329_2.fastq.gz	Fastqsanger.gz
	SRR27297330_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins

Project description:This investigation scrutinizes the implications and mechanistic underpinnings of ursolic acid's effect on busulfan-induced oligospermia in mouse models. A single intraperitoneal injection at a dose of 30mg/kg of busulfan induced oligospermia, and two weeks later, the mice were treated with varied dosages of ursolic acid (10, 30, and 50 mg/kg w.t., respectively) daily for four consecutive weeks. Following this, a meticulous analysis of epididymal sperm parameters encompassing concentration and motility were undertaken using a computer-assisted sperm analysis system. The histopathology of the mice testes was performed utilizing hematoxylin and eosin staining, and the cytoskeleton regeneration of the testicular tissues was analyzed via immunofluorescent staining. Serum hormone levels (including testosterone, luteinizing hormone, and follicle-stimulating hormone) and reactive oxygen species levels (inclusive of reactive oxygen species and malondialdehyde) were gauged employing corresponding specific enzyme-linked immunosorbent assay kits. Differentially expressed genes of testicular mRNA between oligospermia and ursolic acid treatments were identified by RNA sequencing analysis. The results revealed that a dosage of 50 mg/kg ursolic acid treatment could increase the concentration of epididymal sperm in oligospermia mice, promote the recovery of testicular morphology, regulate hormone levels and ameliorate oxidative damage. The mechanism research results indicated that ursolic acid increased the expression level of genes related to motor proteins in oligospermia mice.

2024-02-17 | GSE251662 | GEO

Effects of ursolic acid and tomatidine on skeletal muscle mRNA expression in aged mice.

Project description:For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Weight-matched cohorts of 22-month-old male C57BL/6 mice were provided ad libitum access to standard chow (control) or standard chow supplemented with 0.27% ursolic acid (UA) or 0.05% tomatidine (TM) for 2 months. After the 2 month treatment period, quadriceps femoris muscles were harvested. mRNA levels in muscles harvested from ursolic acid or tomatidine fed mice were normalized to levels in muscles fed control diet.

2015-09-03 | E-GEOD-72651 | biostudies-arrayexpress

Effect of ursolic acid on mouse skeletal muscle mRNA levels

Project description:The goal of these studies was to determine the effects of ursolic acid on skeletal muscle mRNA levels in wild-type mice

2011-06-08 | GSE28017 | GEO

IL-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration

Project description:IL-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration

| PRJNA648916 | ENA

L.J. could rescure the adverse effects induced by busulfan on the spleen

Project description:We report the side-effects of busulfan on the spleen, and foud that the L.J. could rescure the side-effect of busulfan in many factors,such as inflammation and oxidative stress

2024-09-25 | GSE184788 | GEO

L.J. could rescure the adverse effects induced by busulfan on the testis

Project description:We report the side-effects of busulfan on the testis, and foud that the L.J. could rescure the side-effect of busulfan in many factors,such as inflammation and oxidative stress

2024-09-25 | GSE184789 | GEO

L.J. could rescure the adverse effects induced by busulfan on the liver

Project description:We report the side-effects of busulfan on the liver, and foud that the L.J. could rescure the side-effect of busulfan in many factors,such as lipid metabolism and oxidative stress

2024-09-25 | GSE184787 | GEO

L.J. could rescure the adverse effects induced by busulfan on the kidney

Project description:We report the side-effects of busulfan on the kidney, and foud that the L.J. could rescure the side-effect of busulfan in many factors,such as lipid metabolism and oxidative stress

2024-09-25 | GSE184785 | GEO

RNA sequencing analysis of busulfan-treated initial segment-caput epididymis.

Project description:Purpose: The purpose of this study is to characterize genes whose expressions in the initial segment (IS)-caput epididymis were affected by busulfan intraperitoneal injection. Methods: 8-week-old wild-type mice were treated with single intraperitoneal injection of dimethyl sulfoxide (DMSO) or busulfan (40mg/kg body weight) disolved in DMSO and mice were left for 4 weeks until tissue sampling at 12 weeks old. IS-caput epididymal mRNA profiles were generated by deep sequencing, in triplicate, using Illumina NovaSeq6000. Results: RNA-seq data identified differentially expressed transcripts. Conclusions: Our results show that the expression of many genes was affected by busulfan injection.

2024-02-18 | GSE247820 | GEO

Ursolic acid-induced DECR1 degradation via NF-κB/NLRP3 pathway inihibits vascular calcification

Project description:In this study, we repoort the protective effect of ursolic acid (UA) on vascular calcification in chronic kidney disease. To elucidate the molecular mechanism underlying the anti-vascular calcification effect of UA, we performed RNA-seq to identify the gene expresion under UA treatmment.

2024-09-13 | GSE276910 | GEO

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