Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Functional difference between TIF fusion protein and single protein

ABSTRACT: Functional difference between TIF fusion protein and single protein

PROVIDER: PRJNA1055447 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Functional difference between TIF fusion protein and single protein

Project description:TIF is a fusion protein of TFF2-IFNα2-Fc. The same dose of TIF/IFNα2/TFF2 was used to stimulate THP-1 cells respectively in the presence of LPS. After extracting RNA, RNAseq technology was used to screen the expression of significantly differential genes induced by TIF/IFNα2/TFF2.

2023-12-22 | GSE251768 | GEO

The difference between diarrhea piglets and normal piglets

Project description:The difference between diarrhea piglets and normal piglets

| PRJNA792613 | ENA

Difference between sulforaphane and sulforaphene in colon cancer

Project description:Difference between sulforaphane and sulforaphene in colon cancer

| PRJNA729976 | ENA

Molecular mechanism of EPC1-PHF1 fusion protein

Project description:Molecular mechanism of EPC1-PHF1 fusion protein

| PRJNA682174 | ENA

Epigenetic regulation of FLT3 by ZNF384-fusion protein

Project description:Epigenetic regulation of FLT3 by ZNF384-fusion protein

| PRJNA812608 | ENA

Difference in mRNA between fast and slow type muscle fibers

Project description:Difference in mRNA between fast and slow type muscle fibers

| PRJNA647313 | ENA

Protein interaction network reveals the biofunctional difference between vegetative cell and heterocyst in multicellular cyanobacteria

Project description:Protein interaction network reveals the biofunctional difference between vegetative cell and heterocyst in multicellular cyanobacteria

2022-04-26 | PXD025312 |

Transcriptional effects of CSB and the CSB-PGBD3 fusion protein in CSB-null UVSS1KO cells

Project description:Cockayne syndrome is a segmental progeria most often caused by mutations in the CSB gene encoding a SWI/SNF-like ATPase required for transcription-coupled DNA repair (TCR). Over 43 Mya before marmosets diverged from humans, a piggyBac3 (PGBD3) transposable element integrated into intron 5 of the CSB gene. As a result, primate CSB genes now generate both CSB protein and a conserved CSB-PGBD3 fusion protein in which the first 5 exons of CSB are alternatively spliced to the PGBD3 transposase. We show by microarray analysis that expression of the fusion protein alone in CSB-null UV-sensitive syndrome cells (UVSS1KO) cells induces an interferon-like response that resembles both the innate antiviral response and the prolonged interferon response normally maintained by unphosphorylated STAT1 (U-STAT1); moreover, as might be expected based on conservation of the fusion protein, this potentially cytotoxic interferon-like response is largely reversed by coexpression of functional CSB protein. Interestingly, expression of CSB and the CSB-PGBD3 fusion protein together, but neither alone, upregulates the insulin growth factor binding protein IGFBP5 and downregulates IGFBP7, suggesting that the fusion protein may also confer a metabolic advantage, perhaps in the presence of DNA damage. Finally, we show that the fusion protein binds in vitro to members of a dispersed family of 900 internally deleted piggyBac elements known as MER85s, providing a potential mechanism by which the fusion protein could exert widespread effects on gene expression. Our data suggest that the CSB-PGBD3 fusion protein is important in both health and disease, and could play a role in Cockayne syndrome. 12 samples total; 4 gene expression conditions in triplicate; 1 condition is a tag-only negative control

2014-03-20 | E-GEOD-56049 | biostudies-arrayexpress

Fusion protein EWS-FLI1 is incorporated into a protein granule in cells

Project description:Fusion protein EWS-FLI1 is incorporated into a protein granule in cells

| PRJNA647916 | ENA

Functional link between TFIIB and Mediator

Project description:Functional link between TFIIB and Mediator

| PRJEB13355 | ENA