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NCounter mouse immune exhaustion panel in 4t1 breast cancer treated with repeat intratumoral influenza vaccine

ABSTRACT: nCounter mouse immune exhaustion panel in 4t1 breast cancer treated with repeat intratumoral influenza vaccine

PROVIDER: PRJNA1055513 | ENA |

REPOSITORIES: ENA

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nCounter mouse immune exhaustion panel in 4t1 breast cancer treated with repeat intratumoral influenza vaccine

Project description:Murine 4T1 breast cancer was grown in vivo and treated with repeat intratumoral influenza vaccine. Flash frozen tissue evaluated by nCounter mouse immune exhaustion panel.

2023-12-25 | GSE251825 | GEO

NLRP3 deficiency reverts intratumoral T cell exhaustion

Project description:NLRP3 deficiency reverts intratumoral T cell exhaustion

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NLRP3 deficiency reverts intratumoral T cell exhaustion

Project description:CD8+ T cells derived from mice with intact NLRP3 signaling in the tumor microenvironment showed an increased expression of coinhibitory receptors PD-1, TIM-3, 2B4 and LAG-3 compared to CD8+ T cells from PancOVA-bearing Nlrp3-/- mice, indicating that NLRP3 inflammasome activation in the tumor microenvironment mediates IL-18 receptor signaling-induced T cell exhaustion. RNAseq was used to characterised molecular pathways involved in T cell plasticity in the presence and absence of intratumoral NLRP3.

2022-04-14 | GSE200570 | GEO

Nanostring ncounter NHP Immunology V2 panel

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nCounter NanoString Human Immunology V2 panel

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Intratumoral antigen-signalling traps CD8+ T cells to confine exhaustion to the tumour site (scRNA-Seq)

Project description:Immunotherapy advances have been hindered by difficulties tracking the behaviours of lymphocytes following antigen-signalling. Here we present the antigen-receptor signalling reporter (AgRSR) mouse to fate-map lymphocytes responding to antigen at specific times and locations, to determine the behaviour of T cells involved in the tumour immune response. Contrary to reports of ready egress of T cells out of the tumour, we find that intratumoral antigen-signalling traps CD8+ T cells in the tumour. These clonal populations expand and become increasingly exhausted over time. In contrast, antigen- signalled regulatory T cell (Treg) clonal populations readily recirculate out of the tumour. Consequently, intratumoral antigen-signalling acts as a gatekeeper to compartmentalize CD8+ T cell responses – even within the same clonotype, enabling immunity to confine exhaustion to a specific tissue site.

2024-05-25 | GSE266361 | GEO

IL-18R signaling affects transcriptional profile of intratumoral CTLs

Project description:We report that intratumoral IL-18R-deficient T cells show decreased T cell exhaustion in a murine pancreatic cancer model

2022-04-08 | GSE200248 | GEO