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Midkine as a driver of age-related changes and increase in mammary tumorigenesis [bulk RNA-seq]

ABSTRACT: Midkine as a driver of age-related changes and increase in mammary tumorigenesis [bulk RNA-seq]

PROVIDER: PRJNA1055530 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27318449_1.fastq.gz	Fastqsanger.gz
	SRR27318449_2.fastq.gz	Fastqsanger.gz
	SRR27318450_1.fastq.gz	Fastqsanger.gz
	SRR27318450_2.fastq.gz	Fastqsanger.gz
	SRR27318451_1.fastq.gz	Fastqsanger.gz

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis

Project description:Midkine as a driver of age-related changes and increase in mammary tumorigenesis

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis [scATAC-seq]

Project description:Aging is one of the pivotal risk factors for cancer, notably in breast cancer with diagnosis striking at the average age of 62. However, the intricate mechanisms underlying aging and breast cancer susceptibility remain unclear. In this study, we depicted a comprehensive single-cell landscape of gene expression (scRNA-seq) and chromatin accessibility (scATAC-seq) of mammary glands from different aged rats. Mechanically, we revealed midkine, a growth factor secreted by basal epithelial cells, which might mediates the age-related mammary changes, as a validation, we treated young rats with midkine for a month and performed the single-cell transcriptome analysis on those mammary glands. We found midkine could largely mediates the transcriptional shift and hyperproliferation of aged epithelial cell by activating PI3K/AKT-SREBF1 signaling. Furthermore, we find the aging-related accumulation of midkine could largely mediated aging-related changes of mammary gland and promoting the tumorigenesis of breast tumors proved using a well-established Nitroso-N-methylurea (NMU)-induced breast cancer rat model. Our finding identify a promising biomarker and intervention target for both mammary aging and tumorigenesis.

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis [scRNA-seq]

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis [scATAC-seq]

Project description:Midkine as a driver of age-related changes and increase in mammary tumorigenesis [scATAC-seq]

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis [scRNA-seq]

Project description:Midkine as a driver of age-related changes and increase in mammary tumorigenesis [scRNA-seq]

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis [bulk RNA-seq]

2024-08-22 | GSE251832 | GEO

Midkine as a driver of age-related changes and increase in mammary tumorigenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-08-22 | GSE251835 | GEO

Transcription profiling of zebrafish retinal development and photoreceptor regeneration to investigate the roles of midkine-a and midkine-b

Project description:In the retina of adult teleosts, stem cells are sustained in two specialized niches: the ciliary marginal zone (CMZ) and the microenvironment surrounding adult MÃ¼ller glia. Recently, MÃ¼ller glia were identified as the regenerative stem cells in the teleost retina. Secreted signaling molecules that regulate neuronal regeneration in the retina are largely unknown. In a microarray screen to discover such factors, we identified midkine-b (mdkb). Midkine is a highly conserved heparin-binding growth factor with numerous biological functions. The zebrafish genome encodes two distinct midkine genes: mdka and mdkb. Here, we describe the cellular expression of mdka and mdkb during retinal development and the initial, proliferative phase of photoreceptor regeneration. The results show that in the embryonic and larval retina mdka and mdkb are expressed in stem cells, retinal progenitors and neurons in distinct patterns that suggest different functions for the two molecules. Following the selective death of photoreceptors in the adult, mdka and mdkb are co-expressed in horizontal cells and proliferating MÃ¼ller glia and their neurogenic progeny. These data reveal that Mdka and Mdkb are signaling factors present in the retinal stem cell niches in both embryonic and mature retinas, and that their cellular expression is actively modulated during retinal development and regeneration. Experiment Overall Design: As a means to identify genes necessary for photoreceptor regeneration, we evaluated transcriptional in the retina of the zebrafish as photoreceptors are regenerated. Albino zebrafish were dark adapted, then half were exposed to bright constant light and half were returned to normal lighting. After 72hrs of light exposure, retinal RNA was isolated and analysis of gene expression was performed using Affymetriz zebrafish gene arrays.

2009-01-13 | E-GEOD-13999 | biostudies-arrayexpress

The cellular expression of midkine-a and midkine-b during retinal development and photoreceptor regeneration

Project description:In the retina of adult teleosts, stem cells are sustained in two specialized niches: the ciliary marginal zone (CMZ) and the microenvironment surrounding adult Müller glia. Recently, Müller glia were identified as the regenerative stem cells in the teleost retina. Secreted signaling molecules that regulate neuronal regeneration in the retina are largely unknown. In a microarray screen to discover such factors, we identified midkine-b (mdkb). Midkine is a highly conserved heparin-binding growth factor with numerous biological functions. The zebrafish genome encodes two distinct midkine genes: mdka and mdkb. Here, we describe the cellular expression of mdka and mdkb during retinal development and the initial, proliferative phase of photoreceptor regeneration. The results show that in the embryonic and larval retina mdka and mdkb are expressed in stem cells, retinal progenitors and neurons in distinct patterns that suggest different functions for the two molecules. Following the selective death of photoreceptors in the adult, mdka and mdkb are co-expressed in horizontal cells and proliferating Müller glia and their neurogenic progeny. These data reveal that Mdka and Mdkb are signaling factors present in the retinal stem cell niches in both embryonic and mature retinas, and that their cellular expression is actively modulated during retinal development and regeneration.

2008-12-17 | GSE13999 | GEO

EHF is an essential driver of mammary alveolar lineage differentiation and putative suppressor of breast tumorigenesis

Project description:EHF is an essential driver of mammary alveolar lineage differentiation and putative suppressor of breast tumorigenesis

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