Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomics Profiling of the Non-Small Cell Lung Cancer (NSCLC) Microenvironment Reveals Dual Immune Cell-Type Behaviors

ABSTRACT: Transcriptomics Profiling of the Non-Small Cell Lung Cancer (NSCLC) Microenvironment Reveals Dual Immune Cell-Type Behaviors

PROVIDER: PRJNA1055533 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27318700_1.fastq.gz	Fastqsanger.gz
	SRR27318700_2.fastq.gz	Fastqsanger.gz
	SRR27318701_1.fastq.gz	Fastqsanger.gz
	SRR27318701_2.fastq.gz	Fastqsanger.gz
	SRR27318702_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 124

Similar Datasets

Dual-species microarray for assessing gene expression in stromal microenvironment, cancer cells and their interactions

Project description:This SuperSeries is composed of the following subset Series: GSE23054: Dual-species microarray for assessing gene expression in stromal microenvironment, cancer cells and their interactions (v1 array) GSE23364: Dual-species microarray for assessing gene expression in stromal microenvironment, cancer cells and their interactions (v2 array) Refer to individual Series

2010-08-04 | E-GEOD-23377 | biostudies-arrayexpress

Tumor cell-specific Gpx4 deficiency reshaps tumor microenvironment and promotes NSCLC progression.

Project description:Tumor cell-specific Gpx4 deficiency reshaps tumor microenvironment and promotes NSCLC progression.

| PRJNA1182465 | ENA

Tumor cell-specific Gpx4 deficiency reshaps tumor microenvironment and promotes NSCLC progression.

Project description:Knockout or inhibition of glutathione peroxidase 4 (GPX4) induces ferroptosis which has been proposed as a potential therapeutic strategy for cancer. Here we unexpectedly found that inducible knockout of GPX4 in tumor cells significantly promotes non-small cell lung cancer (NSCLC) progression in the autochthonous KrasLSL-G12D/+Lkb1fl/fl (KL) and KrasLSL-G12D/+Tp53fl/fl (KP) mouse models, whereas inducible overexpression of GPX4 in tumor cells had an opposite effect. Mechanistically, knockout of GPX4 in tumor cells results in the accumulation of triacylglycerol (TAG) that was stored in lipid droplets in tumor cells and the efflux of TAG that induces ferroptosis of macrophages in the tumor microenvironment (TME), thereby igniting an immunoinhibitory TME characterized by the dysfunction of anti-tumor T cells and the decrease of antigen-presenting macrophages. Consistently, treatment with liprostatin-1 or inducible overexpression of GPX4 in tumor cells significantly rescues the ferroptosis of macrophages and ignites the activation of T cells in the TME, thereby inhibiting NSCLC progression. These findings highlight a previously uncharacterized role of tumor cell-specific GPX4 in NSCLC progression by modulating TAG metabolism in the TME and provide potential therapeutic strategies for NSCLC.

2024-11-05 | GSE281159 | GEO

Single-cell transcriptomics of dynamic cell behaviors

Project description:Single-cell transcriptomics of dynamic cell behaviors

| PRJNA798600 | ENA

Transcriptomics Profiling of the Non-Small Cell Lung Cancer (NSCLC) Microenvironment Reveals Dual Immune Cell-Type Behaviors

Project description:Lung cancer is the leading cause of cancer death worldwide, with a poor survival rate despite recent therapeutic. A better understanding of the tumor and microenvironnement complexity is needed to improve patients outcome.

2024-10-01 | GSE251840 | GEO

Transcriptome in NSCLC cell lines

Project description:Transcriptome in NSCLC cell lines

| PRJNA808994 | ENA

Microenvironment Cell Populations

Project description:Microenvironment Cell Populations

| PRJNA341521 | ENA

Baseline NSCLC cell lines compared to a reference mix consisting of 45 NSCLC cell lines

Project description:34 NSCLC cell lines were transcriptionally profiled against a reference mix of 45 NSCLC cell lines to look subtype specific differential gene expression 34 individual cell lines were compared to a reference mix consiting of 45 NSCLC cell lines

2013-01-18 | E-GEOD-43567 | biostudies-arrayexpress

Comprehensive Profiling of Cancer Cells and Their Microenvironment in Advanced NSCLC

Project description:Comprehensive Profiling of Cancer Cells and Their Microenvironment in Advanced NSCLC

| PRJNA622993 | ENA

The homing behaviors of hair follicle dermal cells and cell intermigration between hair follicle and perifollicular microenvironment

Project description:The homing behaviors of hair follicle dermal cells and cell intermigration between hair follicle and perifollicular microenvironment

| PRJNA860088 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data