Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination

ABSTRACT: Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination

PROVIDER: PRJNA1055554 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination

Project description:Multivalent presentation of ligands often enhances receptor activation and downstream signaling. DNA origami offers precise nanoscale spacing of ligands, a potentially useful feature for therapeutic nanoparticles. Here, we use a square block DNA origami platform to explore the importance of spacing of CpG oligonucleotides. CpG engages Toll-like receptors and thereby acts to activate dendritic cells. Through in vitro cell-culture studies and in vivo tumor-treatment models, we demonstrate that square blocks induce Th1 immune polarization when CpG is spaced at 3.5 nm. We observe that this DNA origami vaccine enhances DC activation, antigen cross-presentation, CD8+ T cell activation, Th1-polarized CD4+ activation and natural killer cell activation. The vaccine also synergizes effectively with anti-PD-L1 for improved cancer immunotherapy in melanoma and lymphoma models and induces long-term T cell memory. Our results suggest that DNA origami may serve as a platform for controlling adjuvant spacing and co-delivering antigens in vaccines.

2024-02-01 | GSE251850 | GEO

Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity

Project description:Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity

| PRJNA563670 | ENA

Fine-tuning of a CRISPRi screen in the seventh pandemic Vibrio cholerae

Project description:Fine-tuning of a CRISPRi screen in the seventh pandemic Vibrio cholerae

| PRJEB76123 | ENA

Model-driven design of synthetic N-terminal coding sequences for fine-tuning gene expression in yeast and bacteria

Project description:N-terminal coding sequences (NCS) are key regulatory elements for fine-tuning gene expression during translation initiation, the rate-limiting step of translation. However, due to complex combinatory effects of NCS biophysical factors and endogenous regulation, designing NCS remains challenging. Herein, we implemented multi-view learning strategy for model-driven generation of synthetic NCS for Saccharomyces cerevisiae and Bacillus subtilis, which are model microorganisms widely used in the laboratory and industry.

2023-10-31 | GSE186378 | GEO

Fine-tuning Mybl2 levels are required for proper MET process during somatic reprogramming

Project description:Fine-tuning Mybl2 levels are required for proper MET process during somatic reprogramming

| PRJNA420731 | ENA

Identification of plant PKG in GA signaling via fine-tuning GAMYB nuclear localization

Project description:Identification of plant PKG in GA signaling via fine-tuning GAMYB nuclear localization

| PRJNA487793 | ENA

Expanding Hematopoietic Stem Cell pool through Fine tuning of Tpo receptor with diabodies.

Project description:Expanding Hematopoietic Stem Cell pool through Fine tuning of Tpo receptor with diabodies.

| PRJNA474240 | ENA

Fine tuning of epithelial taste bud organoid to promote functional recapitulation of taste reactivity

Project description:Fine tuning of epithelial taste bud organoid to promote functional recapitulation of taste reactivity

| PRJNA789918 | ENA

Translational reprogramming during epithelial-mesenchymal transition is associated with fine-tuning of ribosome composition

Project description:Translational reprogramming during epithelial-mesenchymal transition is associated with fine-tuning of ribosome composition

| PRJNA1032593 | ENA

Reciprocal fine-tuning of progesterone and prolactin-regulated gene expression in breast cancer cells

Project description:Reciprocal fine-tuning of progesterone and prolactin-regulated gene expression in breast cancer cells

| PRJNA632540 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data