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Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation. [CUT&Run]

ABSTRACT: Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation. [CUT&Run]

PROVIDER: PRJNA1057943 | ENA |

REPOSITORIES: ENA

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Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation. [CUT&Run]

Project description:Copper (Cu) is an essential trace element for diverse biological reactions such as respiration, neurotransmitter synthesis, oxidative stress and transcriptional regulation. If Cu homeostasis is disrupted, several pathological conditions can develop, leading to alterations of neuronal, cognitive, and muscular development. Known Cu+-binding transcription factors in mammalian cells are Atox1, Mtf1 and Sp1. We identified Crip2 as a novel Cu+-responsive transcriptional regulator that is required for the differentiation of primary myoblasts derived from mouse satellite cells. Functional characterization of CRISPR/Cas9-mediated deletion of Crip2 showed that myoblasts fail to differentiate and manifest a decrease in expression of the differentiation markers Myogenin and Myosin heavy chain. RNA-seq and CUT&RUN analysis were performed to understand the effect on Crip2 in the regulation of gene expression in proliferating and differentiating primary myoblasts stimulated with Cu.

2024-05-30 | GSE252156 | GEO

Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation.

Project description:Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation.

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Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation. [RNA-Seq]

Project description:Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation. [RNA-Seq]

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Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation. [RNA-Seq]

2024-05-30 | GSE252158 | GEO

Cysteine Rich Protein 2 is a copper-responsive regulator of skeletal muscle differentiation.

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-05-30 | GSE252162 | GEO

Cysteine-rich peptides promote interspecific genetic isolation in Arabidopsis

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A novel copper-responsive regulon in Mycobacterium tuberculosis.

2010-10-27 | GSE23498 | GEO

A novel copper-responsive regulon in Mycobacterium tuberculosis.

Project description:In this study, we report the identification of a five-locus copper-inducible regulon in Mycobacterium tuberculosis. The identification of a copper responsive regulon unique to pathogenic Mycobacteria suggests copper homeostasis must be maintained during an infection. WT and mutant Mtb cells were grown in Sauton's minimal media to early stationary phase (OD580 = 1.5) and treated with 500 mM copper sulfate (CuSO4) for four hours or the absence

2010-10-27 | E-GEOD-23498 | biostudies-arrayexpress

A Novel Copper Responsive Regulon in Mycobacterium tuberculosis strains mpA and pafA

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Differential expression of transcriptome under copper stress in Microcystis aeruginosa. PCC 7806

Project description:The cyanobacterium Microcystis aeruginosa PCC 7806 was used for a systematic survey of the relationship between copper and microcystins synthesis. Here we have used microarrays to interrogate the global responses to copper additions at 0.5 micromolar (µM) and 3 µM of copper. From the gene level, microarray studies (3 µM copper supplementation) showed effects on iron, sulfur, glutaredoxin and dehydratase homeostasis gene expression. However, in 0.5 µM groups, those genes that significantly enriched in 3 µM groups regulatory were not all found. In the microarray data for copper stress (3 µM) revealed a broad effect on the expression of iron-sulphur cluster associated pathways, such as cysteine biosynthesis. All of these data indicate that Fe / S cluster biogenesis and/or repair were affected by copper in M. aeruginosa.

2018-12-21 | GSE108380 | GEO

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