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Homo sapiens

ABSTRACT: Skeletal muscles of untreated children with juvenile dermatomyositis

OTHER RELATED OMICS DATASETS IN: E-GEOD-11971

PROVIDER: PRJNA105845 | ENA |

REPOSITORIES: ENA

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E-GEOD-11971

Project description:Transcription profiling of human muscles from untreated children with juvenile dermatomyositis

2025-01-16 | E-GEOD-11971 | ExpressionAtlas

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Project description:Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis

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Deciphering Spatial Transcriptomic Signatures Reveals Insights into Perifascicular Atrophy in Dermatomyositis

Project description:Dermatomyositis is an autoimmune disease that primarily affects the skin and muscles. Perifascicular atrophy is a characteristic feature of dermatomyositis, yet its underlying mechanisms remain unclear. Hereby we conducted spatial transcriptomics to study the changes in the RNA expression in the muscle fibers with perifascicular atrophy from patients with juvenile and adult dermatomyositis, compared with muscles with non-atrophic areas. Our findings provide new insights into the molecular mechanisms underlying perifascicular atrophy and highlight potential pathways for future investigation.

2025-10-01 | GSE285226 | GEO

RNA-Seq of CD19+ B-cell populations from patients with juvenile dermatomyositis and controls

Project description:RNA sequencing was used to compare the transcriptional state of ex-vivo B-cells from children with Juvenile dermatomyositis (JDM) pre- and on-treatment and age-matched healthy controls. RNA was extracted from blood samples that were taken from juvenile dermatomyositis patients at diagnosis (before they received treatment) and approximately a year into treatment. The treatment included oral prednisolone, methotrexate, azathioprine, cyclophosphamide and other drugs.

2019-01-03 | E-MTAB-5616 | biostudies-arrayexpress

Childhood Onset Rheumatic Disease Gene Expression Profile

2009-03-25 | GSE11083 | GEO

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Project description:MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis

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RNA-Seq of CD19+ B-cell, CD14+ monocyte, CD4+ and CD8+ T cell populations from patients with juvenile dermatomyositis and controls

Project description:RNA sequencing was used to compare the transcriptional state of ex-vivo B-cells, moncytes and T-cells from children with Juvenile dermatomyositis (JDM) pre- and on-treatment and age-matched healthy controls. RNA was extracted from blood samples that were taken from juvenile dermatomyositis patients at diagnosis (before they received treatment) and approximately a year into treatment. The treatment included oral prednisolone, methotrexate, azathioprine, cyclophosphamide and other drugs.

2022-12-31 | GSE221091 | GEO

Childhood Onset Rheumatic Disease Gene Expression Profile

Project description:Total RNA from peripheral blood mononuclear cells (PBMC) and neutrophils from children with juvenile dermatomyositis (JDM) and juvenile idiopathic arthritis (JIA) were separately compared to pediatric control samples. Keywords: pediatric rheumatic disease, blood, PBMC, neutrophil, JIA, JDM JIA PBMC n = 14 JIA neutrophils n=14 JDM PBMC n = 13 JDM neutrophils n = 14 pediatric control PBMC n = 15 pediatric control neutrophils n = 13

2009-03-25 | E-GEOD-11083 | biostudies-arrayexpress

Skeletal muscles of untreated children with juvenile dermatomyositis

Project description:Background :To evaluate the impact of the duration of chronic inflammation on gene expression in skeletal muscle biopsies (MBx) from untreated children with juvenile dermatomyositis (JDM) and identify genes and biological processes associated with the disease progression, expression profiling data from 16 girls with active symptoms of JDM greater or equal to 2 months were compared with 3 girls with active symptoms less than 2 months. Results: Seventy-nine genes were differentially expressed between the groups with long or short duration of untreated disease. Genes involved in immune responses and vasculature remodeling were expressed at a higher level in muscle biopsies from children with greater or equal to 2 months of symptoms, while genes involved in stress responses and protein turnover were expressed at a lower level. Among the 79 genes, expression of 9 genes showed a significant linear regression relationship with the duration of untreated disease. Five differentially expressed genes--HLA-DQA1, smooth muscle myosin heavy chain, clustering, plexin D1 and tenomodulin--were verified by quantitative RT-PCR. The chronic inflammation of longer disease duration was also associated with increased DC-LAMP+ and BDCA2+ mature dendritic cells, identified by immunohistochemistry. Conclusions: We conclude that chronic inflammation alters the gene expression patterns in muscle of untreated children with JDM. Symptoms lasting greater or equal to 2 months were associated with dendritic cell maturation and anti-angiogenic vascular remodelling, directly contributing to disease pathophysiology. Keywords: Disease progression; time course

2008-07-18 | GSE11971 | GEO