Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [DMS-Seq]

ABSTRACT: DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [DMS-Seq]

PROVIDER: PRJNA1060342 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [DMS-Seq]

Project description:Glucose, traditionally recognized as a primary energy source, has recently emerged as a key regulator of protein interactions, particularly when intracellular glucose levels increase during cellular differentiation. Recent research has unveiled the intriguing phenomenon of glucose binding to a variety of proteins. Here, we focus on DDX50, a pivotal RNA helicase with a crucial role in epidermal differentiation. The interaction between glucose and the ATP-binding domain of DDX50 induces a significant change in the protein's conformation, resulting in the dissociation of DDX50 dimers. In the context of cellular differentiation, the increase in glucose levels promotes the formation of a complex involving DDX50, RNA, and STAU1. This complex, in turn, influences RNA structures and functions as a stabilizing force for the mRNA of key pro-differentiation genes. These genes include TINCR, OVOL1, CEBPB, PRDM1 and JUN. These findings reveal a previously unrecognized mechanism by which glucose exerts its influence, demonstrating its remarkable capacity to modulate the dimerization and function of the RNA helicase DDX50, which plays a critical role in tissue differentiation.

2024-12-05 | GSE252404 | GEO

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [ClIP-Seq ddx50]

Project description:DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [ClIP-Seq ddx50]

| PRJNA1059642 | ENA

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs

Project description:DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs

| PRJNA1060656 | ENA

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs

Project description:DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs

| PRJNA1158870 | ENA

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [rna_seq_kc_ddx50_kd]

Project description:DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [rna_seq_kc_ddx50_kd]

| PRJNA1060657 | ENA

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [rna_seq_organoid_ddx50]

Project description:DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [rna_seq_organoid_ddx50]

| PRJNA1059646 | ENA

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [clip_stau1]

Project description:DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [clip_stau1]

| PRJNA1060658 | ENA

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [rna_seq_stability_ddx50]

Project description:DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [rna_seq_stability_ddx50]

| PRJNA1059648 | ENA

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [rna_seq_stability_stau1]

Project description:DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [rna_seq_stability_stau1]

| PRJNA1060353 | ENA

DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAs [ClIP-Seq ddx50]

2024-12-05 | GSE252324 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data