Project description:Deep sequencing of mRNA from Chinese tree shrew; Chinese tree shrew (Tupaia belangeri chinensis) is placed in Order Scandentia and embraces many unique features for a good experimental animal model. Currently, there are many attempts to employ tree shrew to establish model for a variety of human disorders such as social stress, myopia, HCV and HBV infection, and hepatocellular carcinoma .We present here a publicly available annotated genome sequence for Chinese tree shrew. Phylogenomic analysis of tree shrew and other mammalians highly supported its close affinity to primates. Characterization of key factors and signaling pathways of the nervous and immune systems in tree shrews showed that this animal had common and unique features, and had essential genetic basis for being a promising model for biomedical researches. Analysis of ploy(A)+ RNA of different specimens:kidney, pancreas, heart, liver, brain, testis and ovary form Chinese tree shrew
Project description:Deep sequencing of mRNA from Chinese tree shrew; Chinese tree shrew (Tupaia belangeri chinensis) is placed in Order Scandentia and embraces many unique features for a good experimental animal model. Currently, there are many attempts to employ tree shrew to establish model for a variety of human disorders such as social stress, myopia, HCV and HBV infection, and hepatocellular carcinoma .We present here a publicly available annotated genome sequence for Chinese tree shrew. Phylogenomic analysis of tree shrew and other mammalians highly supported its close affinity to primates. Characterization of key factors and signaling pathways of the nervous and immune systems in tree shrews showed that this animal had common and unique features, and had essential genetic basis for being a promising model for biomedical researches.
Project description:Purpose: The goals of this study are to clarify influence of long-term expansion on the spermatogenesis potential of tree shrew spermatogonial stem cells （SSCs）
Project description:To investigate gene expression in the tree shrew pancreatic cancer model, tumor samples were analyzed by RNA-seq and the expression profiles were compared to those of human pancreatic cancer samples (n = 30) containing KRAS, TP53, and CDKN2A/B mutations downloaded from The Cancer Genome Atlas (https://tcga-data.nci.nih.gov/) and mouse pancreatic cancer (accession no. GSE87388), which showed similar histological features
Project description:Tree age groups of T.chinensis–15 days, 3 months and 1.5 years – were selected to study their hippocampal protein expression profiles.
