Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Childhood Cancer Data Initiative (CCDI): Single-cell atlas of NF1 nerve sheath tumors

ABSTRACT: Childhood Cancer Data Initiative (CCDI): Single-cell atlas of NF1 nerve sheath tumors

PROVIDER: PRJNA1062532 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Childhood Cancer Data Initiative (CCDI): Molecular Characterization Initiative

Project description:Childhood Cancer Data Initiative (CCDI): Molecular Characterization Initiative

| PRJNA801748 | ENA

Childhood Cancer Data Initiative (CCDI): Molecular Characterization Initiative

Project description:Childhood Cancer Data Initiative (CCDI): Molecular Characterization Initiative

| PRJNA801718 | ENA

Childhood Cancer Data Initiative (CCDI): PIVOT UT San Antonio

Project description:Childhood Cancer Data Initiative (CCDI): PIVOT UT San Antonio

| PRJNA915173 | ENA

RNAseq of malignant peripheral nerve sheath tumors from Nf1 flox/flox Arf flox/flox PostnCre+ mice

Project description:Malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of premature death for patients with Neurofibromatosis type 1 and no approved targeted therapies are available. Transformation from Nf1-null benign plexiform neurofibromas is driven by the loss of the Cdkn2a (Arf) locus. Here, genetically engineered mouse models with combined Nf1 flox/flox and Arf flox/flox alleles were used (crossed with Postn-Cre+ mice). Tissue from MPNSTs that form in the Nf1-/-;Arf-/- setting were used for mRNA sequencing and compared to benign plexiform neurofibroma tissue (Nf1-/- from Nf1 flox/flox; Postn-Cre+ mice, GSE213789) to identify transcriptome signatures from MPNST and compare them to benign plexiform neurofibroma.

2023-12-12 | GSE232707 | GEO

Spatial gene expression profiling unveils immuno-oncogenic programs of NF1-associated peripheral nerve sheath tumor progression

Project description:Plexiform neurofibromas (PNF) are benign peripheral nerve sheath tumors (PNST) that arise in persons with neurofibromatosis type 1 (NF1). Despite similar histological appearance, these neoplasms proceed along diverse evolutionary trajectories, with a subset progressing to a devastating form of sarcoma called malignant peripheral nerve sheath tumor (MPNST), the leading cause of premature death in individuals with NF1. Malignant transformation of PNF often occurs through the development of atypical neurofibroma (ANF) precursor lesions characterized by distinct histopathological features and CDKN2A copy number loss. While genomic studies have improved our understanding of key driver events promoting tumor progression, the transcriptional alterations that precede malignant transformation remain poorly understood. Here we resolve gene expression profiles in PNSTs across the neurofibroma-to-MPNST continuum in NF1 patients and genetically engineered mouse models, providing insight into nascent molecular features associated with neurofibroma evolution and transformation. These findings highlight the need for molecular diagnostic tools that augment conventional histopathological criteria to identify neurofibromas at high risk of undergoing malignant transformation, facilitating risk-adapted care.

2023-12-14 | GSE239561 | GEO

Childhood Cancer Data Initiative (CCDI): PIVOT Children's Cancer Institute Australia

Project description:Childhood Cancer Data Initiative (CCDI): PIVOT Children's Cancer Institute Australia

| PRJNA915182 | ENA

Childhood Cancer Data Initiative (CCDI): NCI CCSG CCDI Supplement Additional Genomic Submission (Funded to OHSU)

Project description:Childhood Cancer Data Initiative (CCDI): NCI CCSG CCDI Supplement Additional Genomic Submission (Funded to OHSU)

| PRJNA761481 | ENA

Childhood Cancer Data Initiative (CCDI): NCI CCSG CCDI Supplement Additional Genomic Submission (Funded to OHSU)

Project description:Childhood Cancer Data Initiative (CCDI): NCI CCSG CCDI Supplement Additional Genomic Submission (Funded to OHSU)

| PRJNA761482 | ENA

Childhood Cancer Data Initiative (CCDI): Clonal Evolution during Metastatic Spread in HighRrisk Neuroblastoma

Project description:Childhood Cancer Data Initiative (CCDI): Clonal Evolution during Metastatic Spread in HighRrisk Neuroblastoma

| PRJNA899975 | ENA

Childhood Cancer Data Initiative (CCDI): Clonal Evolution during Metastatic Spread in HighRrisk Neuroblastoma

Project description:Childhood Cancer Data Initiative (CCDI): Clonal Evolution during Metastatic Spread in HighRrisk Neuroblastoma

| PRJNA899976 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data