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Heart transcriptional changes with prednisone with inducible cardiomyocyte-specific GR ablation

ABSTRACT: Heart transcriptional changes with prednisone with inducible cardiomyocyte-specific GR ablation

PROVIDER: PRJNA1062780 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27474600_1.fastq.gz	Fastqsanger.gz
	SRR27474600_2.fastq.gz	Fastqsanger.gz
	SRR27474601_1.fastq.gz	Fastqsanger.gz
	SRR27474601_2.fastq.gz	Fastqsanger.gz
	SRR27474602_1.fastq.gz	Fastqsanger.gz

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Heart transcriptional changes with prednisone with inducible cardiomyocyte-specific GR ablation

Project description:this dataset encompasses the cardiac transcriptomic changes elicited in myocardial tissues of 4months-old male mice at 4 hours after a single ZT0 prednisone (1mg/kg i.p.) injection, or vehicle, in cardiomyocyte-GR-WT versus cardiomyocyte-GR-KO conditions (inducible, tamoxifen-driven ablation right prior to drug pulse).

2024-01-13 | GSE252826 | GEO

Heart transcriptional changes with prednisone with inducible cardiomyocyte-specific KLF15 ablation

Project description:this dataset encompasses the cardiac transcriptomic changes elicited in myocardial tissues of 4months-old mice at 4 hours after a single ZT0 prednisone (1mg/kg i.p.) injection, or vehicle, in cardiomyocyte-KLF15-WT versus cardiomyocyte-KLF15-KO conditions (inducible, tamoxifen-driven ablation right prior to drug pulse).

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Heart transcriptional changes with prednisone with inducible cardiomyocyte-specific KLF15 ablation

Project description:Heart transcriptional changes with prednisone with inducible cardiomyocyte-specific KLF15 ablation

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Myocardial GR epigenomic changes with single ZT0 prednisone pulse

Project description:this dataset encompasses the cardiac GR epigenomic changes elicited in 4-month-old mice with a single ZT0 prednisone (1mg/kg i.p.) injection

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Myocardial GR epigenomic changes with single ZT0 prednisone pulse

Project description:Myocardial GR epigenomic changes with single ZT0 prednisone pulse

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Muscle GR and BMAL1 epigenomic binding at ZT4 after vehicle versus prednisone pulse at ZT0

Project description:Exogenous glucocorticoids interact with the circadian clock, but little attention is paid to their time of intake. Here we investigated the epigenetic effects of prednisone in muscle when pulsed as single 1mg/kg i.p. dose in mice WT mice at ZT0, i.e. when endogenous corticosterone is low. At 4-hours post-injection (ZT4), we performed ChIP-seq analysis in muscle tissue for the glucocorticoid receptor (GR), as well as BMAL1, clock factor active in the light-phase. We also performed ChIP-seq for RNApol-II to quantitate changes in RNApol-II recruitment. We repeated the GR and RNApol-II analyses in muscles from BMAL1-knockout mice.

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Muscle epigenomic changes with once-weekly prednisone at 4- vs 24-months of age

Project description:this dataset encompasses the muscle GR epigenomic changes elicited in quadriceps muscles of 4- vs 24-month-old mice (males + females) with a 12-week-long regimen of once-weekly ZT0 prednisone (1mg/kg i.p.)

2023-11-08 | GSE245493 | GEO

Muscle GR and BMAL1 epigenomic binding at ZT4 after vehicle versus prednisone pulse at ZT0

Project description:Muscle GR and BMAL1 epigenomic binding at ZT4 after vehicle versus prednisone pulse at ZT0

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Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

Project description:Background: Genomic and experimental studies suggest a role for PITX2 in atrial fibrillation (AF). To assess whether this association is relevant for recurrent AF in patients, we tested whether left atrial PITX2 affects recurrent AF after AF ablation. Methods: mRNA concentrations of PITX2 and its cardiac isoform, PITX2c, were quantified in left atrial appendages (LAA) from patients undergoing thoracoscopic AF ablation, either in whole LAA tissue (n=83) or in LAA cardiomyocytes (n=52), and combined with clinical parameters to predict AF recurrence. Literature suggests bone morphogenetic protein 10 (BMP10) as a PITX2-repressed, atrial-specific, secreted protein. BMP10 plasma concentrations were combined with eleven cardiovascular biomarkers and clinical parameters to predict recurrent AF after catheter ablation in 359 patients. Results: Reduced cardiomyocyte PITX2 concentrations, but not whole LAA tissue PITX2, were associated with AF recurrence after thoracoscopic AF ablation (16% decreased recurrence per 2-(ΔΔCt) increase in PITX2). RNA sequencing, qPCR and Western blotting confirmed BMP10 as one of most PITX2-repressed atrial genes. Left atrial size (hazard ratio per mm increase, HR [95%CI] 1.055 [1.028, 1.082], non-paroxysmal AF (HR 1.672 [1.206, 2.318]) and elevated BMP10 (HR 1.339 [CI 1.159, 1.546] per quartile increase) were predictive of recurrent AF. BMP10 outperformed eleven other cardiovascular biomarkers in predicting recurrent AF. Conclusions: Reduced left atrial cardiomyocyte PITX2 and elevated plasma concentrations of the PITX2-repressed, secreted, atrial protein BMP10 identify patients at risk of recurrent AF after ablation.

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Effect of cardiomyocyte-specific deletion of glucocorticoid receptor on gene expression of cultured neonatal cardiomyocytes

Project description:To investigate the role of the glucocorticoid receptor (GR) in the regulation of cardiomyocyte maturation and proliferation, we established a cardiomyocyte-specific GR knock-out (GR-cKO) mouse model by Cre-Lox technology. We thus performed gene expression profiling analysis using data obtained from RNA-seq of cardiomyocytes isolated from GR-cKO and control mouse models at neonatal stage and cultured in vitro. Our analyses unveiled a role for GR in regulating gene networks related to the energetic metabolism, which in turn may impact on cardiomyocyte proliferative and regenerative ability.

2022-05-16 | GSE202968 | GEO

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