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Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development

ABSTRACT: Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development

PROVIDER: PRJNA1063352 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27490809_1.fastq.gz	Fastqsanger.gz
	SRR27490809_2.fastq.gz	Fastqsanger.gz
	SRR27490810_1.fastq.gz	Fastqsanger.gz
	SRR27490810_2.fastq.gz	Fastqsanger.gz
	SRR27490811_1.fastq.gz	Fastqsanger.gz

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Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.

Project description:Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) are a major cause for acquired thrombophilia. Here we show that specific inhibition of the TF coagulation initiation complex with nematode anticoagulant protein c2 (NAPc2) prevents the the development of persistent aPL and circulating phospholipid-reactive B1 cells in latent viral infection and lupus prone MRL-lpr mice. NGS mRNA profiling of splenic DC in lupus mice treated with NAPc2 versus saline control uncovered a suppression of dendritic cell activation in the spleen.

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Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.

Project description:Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development.

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Project description:Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) areis a major cause for acquired thrombophilia. Here we test the effect of specific inhibition of the TF coagulation initiation complex with nematode anticoagulant protein c2 (NAPc2) on the activation of monocytes by aPL. NGS data show that aPL-induced proinflammatory and prothrombotic activation of monocytes, but not interferon regulated gene induction is prevent by NAPc2.

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Project description:Genetics of Antiphospholipid Antibody Syndrome (APS) - RTDC 5806

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